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SRI

GENERAL INFORMATION

Gene name

 SRI

Gene description

 Sorcin

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression expression in the brain, urinary bladder, fallopian tube and the gastrointestinal tract.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Paired antibodies with high similarity supports the protein expression.

Reliability score

 Supported based on 2 antibodies.
HPA019004 , HPA073666
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (favourable) and pancreatic cancer (unfavourable).
Lung cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019004
HPA073666

GENE INFORMATION

Gene name

 SRI

Synonyms

Description

 Sorcin (HGNC Symbol)

Entrez gene summary

 This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012]

Chromosome

 7

Cytoband

 q21.12

Chromosome location (bp)

 88205118 - 88226993

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000075142 (version 83.38)

Entrez gene

 6717

UniProt

 P30626 (UniProt - Evidence at protein level)

neXtProt

 NX_P30626

Antibodypedia

 SRI antibodies

PROTEIN BROWSER
SRI-001
SRI-003
SRI-004
SRI-005
SRI-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SRI-001
ENSP00000265729
ENST00000265729
P30626 [Direct mapping]
Sorcin
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001508 [action potential]
GO:0002020 [protease binding]
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005102 [receptor binding]
GO:0005246 [calcium channel regulator activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005790 [smooth endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0006810 [transport]
GO:0006816 [calcium ion transport]
GO:0006880 [intracellular sequestering of iron ion]
GO:0006942 [regulation of striated muscle contraction]
GO:0007165 [signal transduction]
GO:0007507 [heart development]
GO:0007517 [muscle organ development]
GO:0008016 [regulation of heart contraction]
GO:0010459 [negative regulation of heart rate]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0016020 [membrane]
GO:0016529 [sarcoplasmic reticulum]
GO:0030018 [Z disc]
GO:0030315 [T-tubule]
GO:0030424 [axon]
GO:0031982 [vesicle]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0042584 [chromaffin granule membrane]
GO:0042802 [identical protein binding]
GO:0042994 [cytoplasmic sequestering of transcription factor]
GO:0043679 [axon terminus]
GO:0044325 [ion channel binding]
GO:0044326 [dendritic spine neck]
GO:0046982 [protein heterodimerization activity]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0051924 [regulation of calcium ion transport]
GO:0060315 [negative regulation of ryanodine-sensitive calcium-release channel activity]
GO:0070062 [extracellular exosome]
GO:0070491 [repressing transcription factor binding]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:1901077 [regulation of relaxation of muscle]
GO:1901841 [regulation of high voltage-gated calcium channel activity]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:2000678 [negative regulation of transcription regulatory region DNA binding]
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 198 aa
21.7 kDa 		No 0
SRI-003
ENSP00000391148
ENST00000431660
P30626 [Direct mapping]
Sorcin
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001508 [action potential]
GO:0002020 [protease binding]
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005102 [receptor binding]
GO:0005246 [calcium channel regulator activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006810 [transport]
GO:0006880 [intracellular sequestering of iron ion]
GO:0006942 [regulation of striated muscle contraction]
GO:0007165 [signal transduction]
GO:0007517 [muscle organ development]
GO:0008016 [regulation of heart contraction]
GO:0010459 [negative regulation of heart rate]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0016020 [membrane]
GO:0016529 [sarcoplasmic reticulum]
GO:0030018 [Z disc]
GO:0030315 [T-tubule]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0042584 [chromaffin granule membrane]
GO:0042802 [identical protein binding]
GO:0044325 [ion channel binding]
GO:0046982 [protein heterodimerization activity]
GO:0051924 [regulation of calcium ion transport]
GO:0060315 [negative regulation of ryanodine-sensitive calcium-release channel activity]
GO:0070062 [extracellular exosome]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:1901077 [regulation of relaxation of muscle]
GO:1901841 [regulation of high voltage-gated calcium channel activity]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
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 180 aa
20 kDa 		No 0
SRI-004
ENSP00000418512
ENST00000490437
C9J0K6 [Direct mapping]
Sorcin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0006508 [proteolysis]
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 155 aa
17.6 kDa 		No 0
SRI-005
ENSP00000397609
ENST00000419179
B4DHQ6 [Direct mapping]
Sorcin; cDNA FLJ54267, moderately similar to Sorcin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
Show all
 158 aa
17.1 kDa 		No 0
SRI-012
ENSP00000378137
ENST00000394641
P30626 [Direct mapping]
Sorcin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001508 [action potential]
GO:0002020 [protease binding]
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005102 [receptor binding]
GO:0005246 [calcium channel regulator activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006810 [transport]
GO:0006880 [intracellular sequestering of iron ion]
GO:0006942 [regulation of striated muscle contraction]
GO:0007165 [signal transduction]
GO:0007517 [muscle organ development]
GO:0008016 [regulation of heart contraction]
GO:0010459 [negative regulation of heart rate]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0016020 [membrane]
GO:0016529 [sarcoplasmic reticulum]
GO:0030018 [Z disc]
GO:0030315 [T-tubule]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0042584 [chromaffin granule membrane]
GO:0042802 [identical protein binding]
GO:0044325 [ion channel binding]
GO:0046982 [protein heterodimerization activity]
GO:0051924 [regulation of calcium ion transport]
GO:0060315 [negative regulation of ryanodine-sensitive calcium-release channel activity]
GO:0070062 [extracellular exosome]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:1901077 [regulation of relaxation of muscle]
GO:1901841 [regulation of high voltage-gated calcium channel activity]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
Show all
 183 aa
20.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.