Expression of GTSE1 in cancer - Summary - The Human Protein Atlas

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GTSE1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GTSE1
Gene description	G-2 and S-phase expressed 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA060544
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), pancreatic cancer (unfavourable) and lung cancer (unfavourable).
Liver cancer p<0.001 Pancreatic cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA060544

GENE INFORMATION
Gene name	GTSE1 (HGNC Symbol)
Synonyms	B99, GTSE-1
Description	G-2 and S-phase expressed 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q13.31
Chromosome location (bp)	46296741 - 46330810
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000075218 (version 83.38)
Entrez gene	51512
UniProt	Q9NYZ3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NYZ3
Antibodypedia	GTSE1 antibodies

PROTEIN BROWSER

GTSE1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GTSE1-001 ENSP00000415430 ENST00000454366	Q9NYZ3 [Direct mapping] G2 and S phase-expressed protein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005881 [cytoplasmic microtubule] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007017 [microtubule-based process] GO:0016020 [membrane] Show all	739 aa 78.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.