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ADD2

GENERAL INFORMATION

Gene name

 ADD2

Gene description

 Adducin 2 (beta)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (testis cancer)
HPA (cell line):Cell line enhanced (K-562, NTERA-2, SCLC-21H, U-251 MG)
HPA (normal tissue):Group enriched (bone marrow, cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression most abundant in brain and bone marrow.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 3 antibodies.
HPA034509 , HPA034510 , CAB009796
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA034509
HPA034510
CAB009796

GENE INFORMATION

Gene name

 ADD2 (HGNC Symbol)

Synonyms

 ADDB

Description

 Adducin 2 (beta) (HGNC Symbol)

Entrez gene summary

 Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]

Chromosome

 2

Cytoband

 p13.3

Chromosome location (bp)

 70607618 - 70768225

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000075340 (version 83.38)

Entrez gene

 119

UniProt

 P35612 (UniProt - Evidence at protein level)

neXtProt

 NX_P35612

Antibodypedia

 ADD2 antibodies

PROTEIN BROWSER
ADD2-001
ADD2-002
ADD2-005
ADD2-006
ADD2-008
ADD2-009
ADD2-010
ADD2-012
ADD2-014
ADD2-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADD2-001
ENSP00000264436
ENST00000264436
P35612 [Direct mapping]
Beta-adducin
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005516 [calmodulin binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006811 [ion transport]
GO:0008290 [F-actin capping protein complex]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030036 [actin cytoskeleton organization]
GO:0030507 [spectrin binding]
GO:0032092 [positive regulation of protein binding]
GO:0042803 [protein homodimerization activity]
GO:0046982 [protein heterodimerization activity]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051017 [actin filament bundle assembly]
GO:0055085 [transmembrane transport]
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 726 aa
80.9 kDa 		No 0
ADD2-002
ENSP00000347972
ENST00000355733
P35612 [Direct mapping]
Beta-adducin
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005516 [calmodulin binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0008290 [F-actin capping protein complex]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030036 [actin cytoskeleton organization]
GO:0030507 [spectrin binding]
GO:0032092 [positive regulation of protein binding]
GO:0042803 [protein homodimerization activity]
GO:0046982 [protein heterodimerization activity]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051017 [actin filament bundle assembly]
GO:0055085 [transmembrane transport]
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 643 aa
72.7 kDa 		No 0
ADD2-005
ENSP00000388072
ENST00000413157
P35612 [Direct mapping]
Beta-adducin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005516 [calmodulin binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0008290 [F-actin capping protein complex]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030036 [actin cytoskeleton organization]
GO:0030507 [spectrin binding]
GO:0032092 [positive regulation of protein binding]
GO:0042803 [protein homodimerization activity]
GO:0046982 [protein heterodimerization activity]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051017 [actin filament bundle assembly]
GO:0055085 [transmembrane transport]
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 559 aa
62.5 kDa 		No 0
ADD2-006
ENSP00000398112
ENST00000430656
P35612 [Direct mapping]
Beta-adducin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005516 [calmodulin binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0008290 [F-actin capping protein complex]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030036 [actin cytoskeleton organization]
GO:0030507 [spectrin binding]
GO:0032092 [positive regulation of protein binding]
GO:0042803 [protein homodimerization activity]
GO:0046982 [protein heterodimerization activity]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051017 [actin filament bundle assembly]
GO:0055085 [transmembrane transport]
Show all
 575 aa
64.2 kDa 		No 0
ADD2-008
ENSP00000384677
ENST00000407644
P35612 [Direct mapping]
Beta-adducin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005516 [calmodulin binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0008290 [F-actin capping protein complex]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030036 [actin cytoskeleton organization]
GO:0030507 [spectrin binding]
GO:0032092 [positive regulation of protein binding]
GO:0042803 [protein homodimerization activity]
GO:0046982 [protein heterodimerization activity]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051017 [actin filament bundle assembly]
GO:0055085 [transmembrane transport]
Show all
 726 aa
80.9 kDa 		No 0
ADD2-009
ENSP00000414546
ENST00000456320
C9JTM0 [Direct mapping]
Beta-adducin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005856 [cytoskeleton]
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 332 aa
37.4 kDa 		No 0
ADD2-010
ENSP00000412681
ENST00000425976
C9J299 [Direct mapping]
Beta-adducin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005856 [cytoskeleton]
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 143 aa
16.4 kDa 		No 0
ADD2-012
ENSP00000403722
ENST00000447731
C9JJK3 [Direct mapping]
Beta-adducin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 17 aa
1.7 kDa 		No 0
ADD2-014
ENSP00000412357
ENST00000415348
C9J080 [Direct mapping]
Beta-adducin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005856 [cytoskeleton]
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 226 aa
25.4 kDa 		No 0
ADD2-016
ENSP00000430243
ENST00000522886
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 280 aa
31.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.