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RASAL2

GENERAL INFORMATION

Gene name

 RASAL2

Gene description

 RAS protein activator like 2

Protein class

 Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic and membranous expression, most abundant in neuronal cells, squamous epithelium of esophagus and vagina.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA018805 , HPA020453
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable).
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA018805
HPA020453

GENE INFORMATION

Gene name

 RASAL2 (HGNC Symbol)

Synonyms

 nGAP

Description

 RAS protein activator like 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q25.2

Chromosome location (bp)

 178094141 - 178484147

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000075391 (version 83.38)

Entrez gene

 9462

UniProt

 Q9UJF2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UJF2

Antibodypedia

 RASAL2 antibodies

PROTEIN BROWSER
RASAL2-001
RASAL2-002
RASAL2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RASAL2-001
ENSP00000420558
ENST00000462775
Q9UJF2 [Direct mapping]
Ras GTPase-activating protein nGAP
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
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 1139 aa
128.6 kDa 		No 0
RASAL2-002
ENSP00000356621
ENST00000367649
Q9UJF2 [Direct mapping]
Ras GTPase-activating protein nGAP
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 1280 aa
143.9 kDa 		No 0
RASAL2-003
ENSP00000402897
ENST00000433130
H0Y638 [Direct mapping]
Ras GTPase-activating protein nGAP
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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0007165 [signal transduction]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0043087 [regulation of GTPase activity]
GO:0046580 [negative regulation of Ras protein signal transduction]
Show all
 693 aa
77.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.