Expression of MARK3 in cancer - Summary - The Human Protein Atlas

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MARK3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MARK3
Gene description	MAP/microtubule affinity-regulating kinase 3
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA024652
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PROGNOSTIC SUMMARY
Prognostic marker in melanoma (unfavourable).
Melanoma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA024652

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Most cancer tissues displayed weak to moderate cytoplasmic positivity. Colorectal cancer were strongly stained while lymphomas, renal and hepatocellular carcinomas were generally negative.

GENE INFORMATION
Gene name	MARK3 (HGNC Symbol)
Synonyms	CTAK1, KP78, PAR-1A
Description	MAP/microtubule affinity-regulating kinase 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Chromosome	14
Cytoband
Chromosome location (bp)	103385392 - 103503831
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000075413 (version 83.38)
Entrez gene	4140
UniProt	P27448 (UniProt - Evidence at protein level)
neXtProt	NX_P27448
Antibodypedia	MARK3 antibodies

PROTEIN BROWSER

MARK3-001	MARK3-002	MARK3-003	MARK3-004	MARK3-005	MARK3-006	MARK3-007	MARK3-008	MARK3-013	MARK3-014	MARK3-020	MARK3-026

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MARK3-001 ENSP00000411397 ENST00000429436	A0A0A0MT23 [Direct mapping] MAP/microtubule affinity-regulating kinase 3; MAP/microtubule affinity-regulating kinase 3, isoform CRA_b Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	753 aa 84.4 kDa	No	0
MARK3-002 ENSP00000402104 ENST00000440884	A0A0A0MST9 [Direct mapping] MAP/microtubule affinity-regulating kinase 3; MAP/microtubule affinity-regulating kinase 3, isoform CRA_d Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	659 aa 74.1 kDa	No	0
MARK3-003 ENSP00000408092 ENST00000416682	A0A0A0MSZ1 [Direct mapping] MAP/microtubule affinity-regulating kinase 3; MAP/microtubule affinity-regulating kinase 3, isoform CRA_e Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	752 aa 84 kDa	No	1
MARK3-004 ENSP00000303698 ENST00000303622	P27448 [Direct mapping] MAP/microtubule affinity-regulating kinase 3 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0045087 [innate immune response] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0070062 [extracellular exosome] Show all	729 aa 81.4 kDa	No	0
MARK3-005 ENSP00000216288 ENST00000216288	A0A0A0MQR8 [Direct mapping] MAP/microtubule affinity-regulating kinase 3; MAP/microtubule affinity-regulating kinase 3, isoform CRA_f Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	713 aa 79.9 kDa	No	0
MARK3-006 ENSP00000450772 ENST00000553942	P27448 [Direct mapping] MAP/microtubule affinity-regulating kinase 3 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0045087 [innate immune response] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0070062 [extracellular exosome] Show all	744 aa 83.2 kDa	No	0
MARK3-007 ENSP00000450460 ENST00000554627	H0YIY6 [Direct mapping] MAP/microtubule affinity-regulating kinase 3 Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	505 aa 56.5 kDa	No	0
MARK3-008 ENSP00000451623 ENST00000556744	A2SY06 [Direct mapping] MAP/microtubule affinity-regulating kinase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016301 [kinase activity] GO:0016310 [phosphorylation] Show all	331 aa 36.7 kDa	No	0
MARK3-013 ENSP00000454169 ENST00000560417	H0YNV4 [Direct mapping] MAP/microtubule affinity-regulating kinase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	178 aa 20.4 kDa	No	0
MARK3-014 ENSP00000452829 ENST00000561225	H0YKJ3 [Direct mapping] MAP/microtubule affinity-regulating kinase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	129 aa 14.5 kDa	No	0
MARK3-020 ENSP00000452893 ENST00000561314	H0YKP9 [Direct mapping] MAP/microtubule affinity-regulating kinase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		222 aa 24.3 kDa	No	0
MARK3-026 ENSP00000335347 ENST00000335102	J3KNR0 [Direct mapping] MAP/microtubule affinity-regulating kinase 3; MAP/microtubule affinity-regulating kinase 3, isoform CRA_h Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	776 aa 86.9 kDa	No	1

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The Human Protein Atlas

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