Expression of SLC25A3 in cancer - Summary - The Human Protein Atlas

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SLC25A3

TISSUE

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CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	SLC25A3
Gene description	Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
Protein class	Disease related genes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	SLC25A3 (HGNC Symbol)
Synonyms	PHC
Description	Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene catalyzes the transport of phosphate into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. The protein contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. Both the N-terminal and C-terminal regions of this protein protrude toward the cytosol. Multiple alternatively spliced transcript variants have been isolated. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q23.1
Chromosome location (bp)	98593591 - 98606379
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000075415 (version 83.38)
Entrez gene	5250
UniProt	Q00325 (UniProt - Evidence at protein level)
neXtProt	NX_Q00325
Antibodypedia	SLC25A3 antibodies

PROTEIN BROWSER

SLC25A3-001	SLC25A3-002	SLC25A3-004	SLC25A3-005	SLC25A3-007	SLC25A3-008	SLC25A3-013	SLC25A3-014	SLC25A3-015	SLC25A3-016	SLC25A3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC25A3-001 ENSP00000188376 ENST00000188376	Q00325 [Direct mapping] Phosphate carrier protein, mitochondrial A0A024RBE8 [Target identity:100%; Query identity:100%] Solute carrier family 25 (Mitochondrial carrier phosphate carrier), member 3, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005887 [integral component of plasma membrane] GO:0006091 [generation of precursor metabolites and energy] GO:0006810 [transport] GO:0015293 [symporter activity] GO:0015320 [phosphate ion carrier activity] GO:0016020 [membrane] GO:0032403 [protein complex binding] GO:0035435 [phosphate ion transmembrane transport] GO:0070062 [extracellular exosome] Show all	361 aa 40 kDa	No	2
SLC25A3-002 ENSP00000449166 ENST00000548847	F8VVM2 [Direct mapping] Phosphate carrier protein, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0006810 [transport] GO:0016021 [integral component of membrane] Show all	324 aa 36.2 kDa	No	2
SLC25A3-004 ENSP00000448708 ENST00000552981	Q00325 [Direct mapping] Phosphate carrier protein, mitochondrial A0A024RBE8 [Target identity:100%; Query identity:100%] Solute carrier family 25 (Mitochondrial carrier phosphate carrier), member 3, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005887 [integral component of plasma membrane] GO:0006091 [generation of precursor metabolites and energy] GO:0006810 [transport] GO:0015293 [symporter activity] GO:0015320 [phosphate ion carrier activity] GO:0016020 [membrane] GO:0032403 [protein complex binding] GO:0035435 [phosphate ion transmembrane transport] GO:0070062 [extracellular exosome] Show all	361 aa 40 kDa	No	2
SLC25A3-005 ENSP00000447310 ENST00000551917	Q00325 [Direct mapping] Phosphate carrier protein, mitochondrial A0A024RBH9 [Target identity:100%; Query identity:100%] Solute carrier family 25 (Mitochondrial carrier phosphate carrier), member 3, isoform CRA_b Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005887 [integral component of plasma membrane] GO:0006091 [generation of precursor metabolites and energy] GO:0006810 [transport] GO:0015293 [symporter activity] GO:0015320 [phosphate ion carrier activity] GO:0016020 [membrane] GO:0032403 [protein complex binding] GO:0035435 [phosphate ion transmembrane transport] GO:0070062 [extracellular exosome] Show all	362 aa 40.1 kDa	No	3
SLC25A3-007 ENSP00000447740 ENST00000549338	Q00325 [Direct mapping] Phosphate carrier protein, mitochondrial A0A024RBE8 [Target identity:100%; Query identity:100%] Solute carrier family 25 (Mitochondrial carrier phosphate carrier), member 3, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005887 [integral component of plasma membrane] GO:0006091 [generation of precursor metabolites and energy] GO:0006810 [transport] GO:0015293 [symporter activity] GO:0015320 [phosphate ion carrier activity] GO:0016020 [membrane] GO:0032403 [protein complex binding] GO:0035435 [phosphate ion transmembrane transport] GO:0070062 [extracellular exosome] Show all	361 aa 40 kDa	No	2
SLC25A3-008 ENSP00000383898 ENST00000401722	Q00325 [Direct mapping] Phosphate carrier protein, mitochondrial A0A024RBE8 [Target identity:100%; Query identity:100%] Solute carrier family 25 (Mitochondrial carrier phosphate carrier), member 3, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005887 [integral component of plasma membrane] GO:0006091 [generation of precursor metabolites and energy] GO:0006810 [transport] GO:0015293 [symporter activity] GO:0015320 [phosphate ion carrier activity] GO:0016020 [membrane] GO:0032403 [protein complex binding] GO:0035435 [phosphate ion transmembrane transport] GO:0070062 [extracellular exosome] Show all	361 aa 40 kDa	No	2
SLC25A3-013 ENSP00000447339 ENST00000548046	F8VZL5 [Direct mapping] Phosphate carrier protein, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0006810 [transport] GO:0016021 [integral component of membrane] Show all	153 aa 16.6 kDa	No	1
SLC25A3-014 ENSP00000449479 ENST00000550695	F8VWR4 [Direct mapping] Phosphate carrier protein, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0006810 [transport] GO:0016021 [integral component of membrane] Show all	154 aa 16.8 kDa	No	1
SLC25A3-015 ENSP00000449793 ENST00000547534	F8VWQ0 [Direct mapping] Phosphate carrier protein, mitochondrial Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0006810 [transport] GO:0016021 [integral component of membrane] Show all	156 aa 16.9 kDa	No	0
SLC25A3-016 ENSP00000448969 ENST00000551265	F8VYH5 [Direct mapping] Phosphate carrier protein, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] Show all	122 aa 12.9 kDa	No	0
SLC25A3-201 ENSP00000228318 ENST00000228318	Q00325 [Direct mapping] Phosphate carrier protein, mitochondrial A0A024RBH9 [Target identity:100%; Query identity:100%] Solute carrier family 25 (Mitochondrial carrier phosphate carrier), member 3, isoform CRA_b Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005887 [integral component of plasma membrane] GO:0006091 [generation of precursor metabolites and energy] GO:0006810 [transport] GO:0015293 [symporter activity] GO:0015320 [phosphate ion carrier activity] GO:0016020 [membrane] GO:0032403 [protein complex binding] GO:0035435 [phosphate ion transmembrane transport] GO:0043209 [myelin sheath] GO:0070062 [extracellular exosome] Show all	362 aa 40.1 kDa	No	3

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.