Expression of CACNG5 in cancer - Summary - The Human Protein Atlas

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CACNG5

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CACNG5
Gene description	Calcium channel, voltage-dependent, gamma subunit 5
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (glioma)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

RNA-based expert annotation gave inconclusive results.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. HPA050115
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA050115

GENE INFORMATION
Gene name	CACNG5
Synonyms
Description	Calcium channel, voltage-dependent, gamma subunit 5 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. This gene is a susceptibility locus for schizophrenia and bipolar disorder. [provided by RefSeq, Dec 2010]
Chromosome	17
Cytoband	q24.2
Chromosome location (bp)	66835117 - 66885486
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000075429 (version 83.38)
Entrez gene	27091
UniProt	Q9UF02 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UF02
Antibodypedia	CACNG5 antibodies

PROTEIN BROWSER

CACNG5-001	CACNG5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CACNG5-001 ENSP00000436836 ENST00000533854	Q9UF02 [Direct mapping] Voltage-dependent calcium channel gamma-5 subunit Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0006810 [transport] GO:0014069 [postsynaptic density] GO:0015075 [ion transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0016247 [channel regulator activity] GO:0019226 [transmission of nerve impulse] GO:0030054 [cell junction] GO:0032281 [AMPA glutamate receptor complex] GO:0045211 [postsynaptic membrane] GO:0070588 [calcium ion transmembrane transport] GO:2000311 [regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity] Show all	275 aa 30.9 kDa	No	3
CACNG5-201 ENSP00000303092 ENST00000307139	Q9UF02 [Direct mapping] Voltage-dependent calcium channel gamma-5 subunit Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0006810 [transport] GO:0014069 [postsynaptic density] GO:0015075 [ion transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0016247 [channel regulator activity] GO:0019226 [transmission of nerve impulse] GO:0030054 [cell junction] GO:0032281 [AMPA glutamate receptor complex] GO:0045211 [postsynaptic membrane] GO:0070588 [calcium ion transmembrane transport] GO:2000311 [regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity] Show all	275 aa 30.9 kDa	No	3

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.