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FSCN1

GENERAL INFORMATION

Gene name

 FSCN1

Gene description

 Fascin actin-bundling protein 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BEWO)
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in cells in seminiferous tubules, glial cells, endothelial cells, fibroblasts and macrophages.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images. Paired antibodies with high similarity supports the protein expression profile.

Reliability score

 Supported based on 4 antibodies.
HPA005723 , HPA050654 , CAB000121 , CAB035991
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), lung cancer (unfavourable) and head and neck cancer (unfavourable).
Renal cancer p<0.001
Lung cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA005723
HPA050654
CAB000121
CAB035991

GENE INFORMATION

Gene name

 FSCN1 (HGNC Symbol)

Synonyms

 FLJ38511, p55, SNL

Description

 Fascin actin-bundling protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]

Chromosome

 7

Cytoband

 p22.1

Chromosome location (bp)

 5592823 - 5606655

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000075618 (version 83.38)

Entrez gene

 6624

UniProt

 Q16658 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16658

Antibodypedia

 FSCN1 antibodies

PROTEIN BROWSER
FSCN1-001
FSCN1-003
FSCN1-004
FSCN1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FSCN1-001
ENSP00000371798
ENST00000382361
Q16658 [Direct mapping]
Fascin
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001725 [stress fiber]
GO:0001726 [ruffle]
GO:0002102 [podosome]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005902 [microvillus]
GO:0005911 [cell-cell junction]
GO:0007043 [cell-cell junction assembly]
GO:0008144 [drug binding]
GO:0008283 [cell proliferation]
GO:0010592 [positive regulation of lamellipodium assembly]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0030027 [lamellipodium]
GO:0030035 [microspike assembly]
GO:0030036 [actin cytoskeleton organization]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0030674 [protein binding, bridging]
GO:0031253 [cell projection membrane]
GO:0032534 [regulation of microvillus assembly]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0035089 [establishment of apical/basal cell polarity]
GO:0043209 [myelin sheath]
GO:0044393 [microspike]
GO:0044822 [poly(A) RNA binding]
GO:0048870 [cell motility]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0051491 [positive regulation of filopodium assembly]
GO:0070062 [extracellular exosome]
GO:0071437 [invadopodium]
GO:0071803 [positive regulation of podosome assembly]
GO:0090091 [positive regulation of extracellular matrix disassembly]
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 493 aa
54.5 kDa 		No 0
FSCN1-003
ENSP00000404506
ENST00000444748
C9JFC0 [Direct mapping]
Fascin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0007015 [actin filament organization]
GO:0016477 [cell migration]
GO:0030674 [protein binding, bridging]
GO:0051015 [actin filament binding]
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 132 aa
14.8 kDa 		No 0
FSCN1-004
ENSP00000409967
ENST00000447103
C9JPH9 [Direct mapping]
Fascin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0007015 [actin filament organization]
GO:0016477 [cell migration]
GO:0030674 [protein binding, bridging]
GO:0051015 [actin filament binding]
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 120 aa
13.5 kDa 		No 0
FSCN1-005
ENSP00000383982
ENST00000405801
A0A0A0MSB2 [Direct mapping]
Fascin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007015 [actin filament organization]
GO:0016477 [cell migration]
GO:0030674 [protein binding, bridging]
GO:0051015 [actin filament binding]
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 138 aa
15.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.