Cell atlas - MOCOS - The Human Protein Atlas

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MOCOS

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Mitochondria

Human cell
	Cytosol
	Mitochondria

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GENERAL INFORMATION
Gene name	MOCOS
Gene description	Molybdenum cofactor sulfurase
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria. In addition localized to the cytosol.
RNA cell category	Cell line enhanced (SiHa, SK-MEL-30, hTCEpi)
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA047958
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SiHa, SK-MEL-30, hTCEpi) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria. In addition localized to the cytosol.

Main location

Mitochondria (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA047958	RT4	Mitochondria
	HPA047958	RT4	Cytosol
	HPA047958	SiHa	Mitochondria
	HPA047958	U-2 OS	Mitochondria
	HPA047958	U-2 OS	Cytosol

GENE INFORMATION
Gene name	MOCOS (HGNC Symbol)
Synonyms	FLJ20733, HMCS, MOS
Description	Molybdenum cofactor sulfurase (HGNC Symbol)
Entrez gene summary	MOCOS sulfurates the molybdenum cofactor of xanthine dehydrogenase (XDH; MIM 607633) and aldehyde oxidase (AOX1; MIM 602841), which is required for their enzymatic activities (Ichida et al., 2001 [PubMed 11302742]).[supplied by OMIM, Feb 2010]
Chromosome	18
Cytoband	q12.2
Chromosome location (bp)	36187519 - 36272157
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000075643 (version 83.38)
Entrez gene	55034
UniProt	Q96EN8 (UniProt - Evidence at protein level)
neXtProt	NX_Q96EN8
Antibodypedia	MOCOS antibodies

PROTEIN BROWSER

MOCOS-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MOCOS-001 ENSP00000261326 ENST00000261326	Q96EN8 [Direct mapping] Molybdenum cofactor sulfurase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005829 [cytosol] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006777 [Mo-molybdopterin cofactor biosynthetic process] GO:0008265 [Mo-molybdopterin cofactor sulfurase activity] GO:0016740 [transferase activity] GO:0016829 [lyase activity] GO:0030151 [molybdenum ion binding] GO:0030170 [pyridoxal phosphate binding] GO:0032324 [molybdopterin cofactor biosynthetic process] GO:0043545 [molybdopterin cofactor metabolic process] GO:0044281 [small molecule metabolic process] Show all	888 aa 98.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.