Fields »
ABOUT
HELP
BLOG
SART3

GENERAL INFORMATION

Gene name

 SART3

Gene description

 Squamous cell carcinoma antigen recognized by T cells 3

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous mainly nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA044322
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and melanoma (unfavourable).
Liver cancer p<0.001
Melanoma p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044322

GENE INFORMATION

Gene name

 SART3 (HGNC Symbol)

Synonyms

 KIAA0156, p110, RP11-13G14, TIP110

Description

 Squamous cell carcinoma antigen recognized by T cells 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q23.3

Chromosome location (bp)

 108522580 - 108561400

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000075856 (version 83.38)

Entrez gene

 9733

UniProt

 Q15020 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15020

Antibodypedia

 SART3 antibodies

PROTEIN BROWSER
SART3-001
SART3-005
SART3-006
SART3-008
SART3-011
SART3-015
SART3-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SART3-001
ENSP00000228284
ENST00000228284
Q15020 [Direct mapping]
Squamous cell carcinoma antigen recognized by T-cells 3
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000244 [spliceosomal tri-snRNP complex assembly]
GO:0000245 [spliceosomal complex assembly]
GO:0000387 [spliceosomal snRNP assembly]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000902 [cell morphogenesis]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005691 [U6atac snRNP]
GO:0005737 [cytoplasm]
GO:0006334 [nucleosome assembly]
GO:0006396 [RNA processing]
GO:0010468 [regulation of gene expression]
GO:0015030 [Cajal body]
GO:0016607 [nuclear speck]
GO:0017070 [U6 snRNA binding]
GO:0030621 [U4 snRNA binding]
GO:0030624 [U6atac snRNA binding]
GO:0042393 [histone binding]
GO:0044822 [poly(A) RNA binding]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0048872 [homeostasis of number of cells]
GO:0071001 [U4/U6 snRNP]
GO:0071002 [U4atac/U6atac snRNP]
GO:0071425 [hematopoietic stem cell proliferation]
GO:1903586 [positive regulation of histone deubiquitination]
GO:1990381 [ubiquitin-specific protease binding]
Show all
 963 aa
109.9 kDa 		No 0
SART3-005
ENSP00000414453
ENST00000431469
Q15020 [Direct mapping]
Squamous cell carcinoma antigen recognized by T-cells 3
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000244 [spliceosomal tri-snRNP complex assembly]
GO:0000245 [spliceosomal complex assembly]
GO:0000387 [spliceosomal snRNP assembly]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005691 [U6atac snRNP]
GO:0005737 [cytoplasm]
GO:0006334 [nucleosome assembly]
GO:0006396 [RNA processing]
GO:0010468 [regulation of gene expression]
GO:0015030 [Cajal body]
GO:0016607 [nuclear speck]
GO:0017070 [U6 snRNA binding]
GO:0030621 [U4 snRNA binding]
GO:0030624 [U6atac snRNA binding]
GO:0042393 [histone binding]
GO:0044822 [poly(A) RNA binding]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0071001 [U4/U6 snRNP]
GO:0071002 [U4atac/U6atac snRNP]
GO:1903586 [positive regulation of histone deubiquitination]
GO:1990381 [ubiquitin-specific protease binding]
Show all
 927 aa
105.6 kDa 		No 0
SART3-006
ENSP00000449386
ENST00000546815
F8VV04 [Direct mapping]
Squamous cell carcinoma antigen recognized by T-cells 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005622 [intracellular]
GO:0006396 [RNA processing]
Show all
 771 aa
89 kDa 		No 0
SART3-008
ENSP00000447324
ENST00000550322
F8VZM2 [Direct mapping]
Squamous cell carcinoma antigen recognized by T-cells 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006396 [RNA processing]
Show all
 156 aa
18.2 kDa 		No 0
SART3-011
ENSP00000447875
ENST00000547397
H0YHU8 [Direct mapping]
Squamous cell carcinoma antigen recognized by T-cells 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 144 aa
16.1 kDa 		No 0
SART3-015
ENSP00000449602
ENST00000550619
F8VVK9 [Direct mapping]
Squamous cell carcinoma antigen recognized by T-cells 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006396 [RNA processing]
Show all
 111 aa
12.8 kDa 		No 0
SART3-017
ENSP00000448554
ENST00000546611
Q15020 [Direct mapping]
Squamous cell carcinoma antigen recognized by T-cells 3
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000244 [spliceosomal tri-snRNP complex assembly]
GO:0000245 [spliceosomal complex assembly]
GO:0000387 [spliceosomal snRNP assembly]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005691 [U6atac snRNP]
GO:0005737 [cytoplasm]
GO:0006334 [nucleosome assembly]
GO:0010468 [regulation of gene expression]
GO:0015030 [Cajal body]
GO:0016607 [nuclear speck]
GO:0017070 [U6 snRNA binding]
GO:0030621 [U4 snRNA binding]
GO:0030624 [U6atac snRNA binding]
GO:0042393 [histone binding]
GO:0044822 [poly(A) RNA binding]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0071001 [U4/U6 snRNP]
GO:0071002 [U4atac/U6atac snRNP]
GO:1903586 [positive regulation of histone deubiquitination]
GO:1990381 [ubiquitin-specific protease binding]
Show all
 129 aa
13.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.