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RBMS2

GENERAL INFORMATION

Gene name

 RBMS2

Gene description

 RNA binding motif, single stranded interacting protein 2

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA039225
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039225

GENE INFORMATION

Gene name

 RBMS2 (HGNC Symbol)

Synonyms

 SCR3

Description

 RNA binding motif, single stranded interacting protein 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. The RBMS proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. This protein was isolated by phenotypic complementation of cdc2 and cdc13 mutants of yeast and is thought to suppress cdc2 and cdc13 mutants through the induction of translation of cdc2. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.3

Chromosome location (bp)

 56521929 - 56596196

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000076067 (version 83.38)

Entrez gene

 5939

UniProt

 Q15434 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15434

Antibodypedia

 RBMS2 antibodies

PROTEIN BROWSER
RBMS2-001
RBMS2-003
RBMS2-004
RBMS2-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RBMS2-001
ENSP00000262031
ENST00000262031
Q15434 [Direct mapping]
RNA-binding motif, single-stranded-interacting protein 2
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005634 [nucleus]
GO:0006396 [RNA processing]
GO:0044822 [poly(A) RNA binding]
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 407 aa
44 kDa 		No 0
RBMS2-003
ENSP00000443486
ENST00000542360
F5H5C8 [Direct mapping]
RNA-binding motif, single-stranded-interacting protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 262 aa
28.8 kDa 		No 0
RBMS2-004
ENSP00000449678
ENST00000550726
F8VV01 [Direct mapping]
RNA-binding motif, single-stranded-interacting protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
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 282 aa
30.7 kDa 		No 0
RBMS2-006
ENSP00000447426
ENST00000552247
F8W1T6 [Direct mapping]
RNA-binding motif, single-stranded-interacting protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
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 344 aa
37.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.