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Malignancies displayed moderate to strong cytoplasmic immunoreactivity. A few testicular seminomas exhibited additional strong nuclear staining. Malignant lymphomas and several gliomas were weakly stained or negative.
GENE INFORMATION
Gene name
UNG (HGNC Symbol)
Synonyms
DGU, HIGM4, UDG, UNG1, UNG2
Description
Uracil DNA glycosylase (HGNC Symbol)
Entrez gene summary
This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003684 [damaged DNA binding] GO:0004844 [uracil DNA N-glycosylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0006281 [DNA repair] GO:0006284 [base-excision repair] GO:0006285 [base-excision repair, AP site formation] GO:0016032 [viral process] GO:0016446 [somatic hypermutation of immunoglobulin genes] GO:0016447 [somatic recombination of immunoglobulin gene segments] GO:0016799 [hydrolase activity, hydrolyzing N-glycosyl compounds] GO:0043066 [negative regulation of apoptotic process] GO:0045008 [depyrimidination] GO:0045830 [positive regulation of isotype switching]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)