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Most cancer tissues showed moderate to strong cytoplasmic positivity. Additional nuclear positivity was observed in a few cases of squamous cell carcinomas, colorectal, pancreatic and liver cancers. Several cases of malignant lymphomas, cervical and renal cancers were weakly stained or negative.
GENE INFORMATION
Gene name
FMO4 (HGNC Symbol)
Synonyms
FMO2
Description
Flavin containing monooxygenase 4 (HGNC Symbol)
Entrez gene summary
Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015]