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KLHL20

GENERAL INFORMATION

Gene name

 KLHL20

Gene description

 Kelch-like family member 20

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA025034 , HPA053704
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA025034
HPA053704

GENE INFORMATION

Gene name

 KLHL20 (HGNC Symbol)

Synonyms

 KHLHX, KLEIP

Description

 Kelch-like family member 20 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 44-56 amino acid repeat motif. The kelch motif appears in many different polypeptide contexts and contains multiple potential protein-protein contact sites. Members of this family are present both throughout the cell and extracellularly, with diverse activities. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q25.1

Chromosome location (bp)

 173714941 - 173786702

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000076321 (version 83.38)

Entrez gene

 27252

UniProt

 Q9Y2M5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y2M5

Antibodypedia

 KLHL20 antibodies

PROTEIN BROWSER
KLHL20-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KLHL20-001
ENSP00000209884
ENST00000209884
Q9Y2M5 [Direct mapping]
Kelch-like protein 20
A0A024R940 [Target identity:100%; Query identity:100%]
Kelch-like 20 (Drosophila), isoform CRA_b
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0003779 [actin binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0006895 [Golgi to endosome transport]
GO:0007010 [cytoskeleton organization]
GO:0015031 [protein transport]
GO:0015629 [actin cytoskeleton]
GO:0016567 [protein ubiquitination]
GO:0016605 [PML body]
GO:0019964 [interferon-gamma binding]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
GO:0035455 [response to interferon-alpha]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:1990390 [protein K33-linked ubiquitination]
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 609 aa
68 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.