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SPAG5

GENERAL INFORMATION

Gene name

 SPAG5

Gene description

 Sperm associated antigen 5

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression at variable levels in most tissues, including testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA022008 , HPA022479
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA022008
HPA022479

GENE INFORMATION

Gene name

 SPAG5 (HGNC Symbol)

Synonyms

 DEEPEST, hMAP126, MAP126

Description

 Sperm associated antigen 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q11.2

Chromosome location (bp)

 28577565 - 28599279

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000076382 (version 83.38)

Entrez gene

 10615

UniProt

 Q96R06 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96R06

Antibodypedia

 SPAG5 antibodies

PROTEIN BROWSER
SPAG5-001
SPAG5-003
SPAG5-005
SPAG5-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SPAG5-001
ENSP00000323300
ENST00000321765
Q96R06 [Direct mapping]
Sperm-associated antigen 5
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000070 [mitotic sister chromatid segregation]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005876 [spindle microtubule]
GO:0007051 [spindle organization]
GO:0007059 [chromosome segregation]
GO:0030496 [midbody]
GO:0035371 [microtubule plus-end]
GO:0051294 [establishment of spindle orientation]
GO:0051301 [cell division]
GO:0051988 [regulation of attachment of spindle microtubules to kinetochore]
GO:0072686 [mitotic spindle]
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 1193 aa
134.4 kDa 		No 0
SPAG5-003
ENSP00000444223
ENST00000536674
F5GZT2 [Direct mapping]
Sperm-associated antigen 5
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 272 aa
29.7 kDa 		No 0
SPAG5-005
ENSP00000463095
ENST00000584206
J3KTQ0 [Direct mapping]
Sperm-associated antigen 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 239 aa
27.3 kDa 		No 0
SPAG5-015
ENSP00000466061
ENST00000582076
K7ELG0 [Direct mapping]
Sperm-associated antigen 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 185 aa
22.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.