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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ACACB
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ACACB

Gene description

Acetyl-CoA carboxylase beta

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Tissue enriched (adipose tissue)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues, most abundant in adipocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

Supported based on 1 antibody.
HPA006554
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA006554

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Strong cytoplasmic staining was observed in one case of liver cancer. All other cancer tissues were essentially negative.

GENE INFORMATION

Gene name

ACACB (HGNC Symbol)

Synonyms

ACC2, ACCB, HACC275

Description

Acetyl-CoA carboxylase beta (HGNC Symbol)

Entrez gene summary

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

q24.11

Chromosome location (bp)

109116595 - 109268226

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000076555 (version 83.38)

Entrez gene

32

UniProt

O00763 (UniProt - Evidence at protein level)

neXtProt

NX_O00763

Antibodypedia

ACACB antibodies

PROTEIN BROWSER

ACACB-001
ACACB-002
ACACB-005
ACACB-201
ACACB-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACACB-001
ENSP00000341044
ENST00000338432
O00763 [Direct mapping]
Acetyl-CoA carboxylase 2 Biotin carboxylase
Show all
Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003989 [acetyl-CoA carboxylase activity]
GO:0004075 [biotin carboxylase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006084 [acetyl-CoA metabolic process]
GO:0006112 [energy reserve metabolic process]
GO:0006633 [fatty acid biosynthetic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006768 [biotin metabolic process]
GO:0006853 [carnitine shuttle]
GO:0010629 [negative regulation of gene expression]
GO:0010884 [positive regulation of lipid storage]
GO:0010906 [regulation of glucose metabolic process]
GO:0012505 [endomembrane system]
GO:0016874 [ligase activity]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0031667 [response to nutrient levels]
GO:0031999 [negative regulation of fatty acid beta-oxidation]
GO:0043086 [negative regulation of catalytic activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046322 [negative regulation of fatty acid oxidation]
GO:0046872 [metal ion binding]
GO:0050995 [negative regulation of lipid catabolic process]
GO:0051289 [protein homotetramerization]
GO:0060421 [positive regulation of heart growth]
GO:0097009 [energy homeostasis]
GO:2001295 [malonyl-CoA biosynthetic process]
Show all
2458 aa
276.5 kDa
Yes 0
ACACB-002
ENSP00000474680
ENST00000544726
S4R3S7 [Direct mapping]
Acetyl-CoA carboxylase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004075 [biotin carboxylase activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
Show all
155 aa
17.6 kDa
No 0
ACACB-005
ENSP00000443494
ENST00000539864
F5H5C3 [Direct mapping]
Acetyl-CoA carboxylase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
143 aa
15.1 kDa
No 0
ACACB-201
ENSP00000367079
ENST00000377848
O00763 [Direct mapping]
Acetyl-CoA carboxylase 2 Biotin carboxylase
Show all
Enzymes
   ENZYME proteins
   Ligase
   MEMSAT-SVM predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003989 [acetyl-CoA carboxylase activity]
GO:0004075 [biotin carboxylase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006084 [acetyl-CoA metabolic process]
GO:0006112 [energy reserve metabolic process]
GO:0006633 [fatty acid biosynthetic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006768 [biotin metabolic process]
GO:0006853 [carnitine shuttle]
GO:0012505 [endomembrane system]
GO:0016874 [ligase activity]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0051289 [protein homotetramerization]
GO:2001295 [malonyl-CoA biosynthetic process]
Show all
2458 aa
276.5 kDa
Yes 0
ACACB-202
ENSP00000367085
ENST00000377854
F8W8T8 [Direct mapping]
Acetyl-CoA carboxylase 2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003989 [acetyl-CoA carboxylase activity]
GO:0005524 [ATP binding]
GO:0006633 [fatty acid biosynthetic process]
GO:0016874 [ligase activity]
Show all
858 aa
97.4 kDa
No 0

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