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ACACB

GENERAL INFORMATION

Gene name

 ACACB

Gene description

 Acetyl-CoA carboxylase beta

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Tissue enriched (adipose tissue)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in several tissues, most abundant in adipocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Supported based on 1 antibody.
HPA006554
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA006554

GENE INFORMATION

Gene name

 ACACB (HGNC Symbol)

Synonyms

 ACC2, ACCB, HACC275

Description

 Acetyl-CoA carboxylase beta (HGNC Symbol)

Entrez gene summary

 Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q24.11

Chromosome location (bp)

 109116595 - 109268226

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000076555 (version 83.38)

Entrez gene

 32

UniProt

 O00763 (UniProt - Evidence at protein level)

neXtProt

 NX_O00763

Antibodypedia

 ACACB antibodies

PROTEIN BROWSER
ACACB-001
ACACB-002
ACACB-005
ACACB-201
ACACB-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACACB-001
ENSP00000341044
ENST00000338432
O00763 [Direct mapping]
Acetyl-CoA carboxylase 2 Biotin carboxylase
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Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003989 [acetyl-CoA carboxylase activity]
GO:0004075 [biotin carboxylase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006084 [acetyl-CoA metabolic process]
GO:0006112 [energy reserve metabolic process]
GO:0006633 [fatty acid biosynthetic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006768 [biotin metabolic process]
GO:0006853 [carnitine shuttle]
GO:0010629 [negative regulation of gene expression]
GO:0010884 [positive regulation of lipid storage]
GO:0010906 [regulation of glucose metabolic process]
GO:0012505 [endomembrane system]
GO:0016874 [ligase activity]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0031667 [response to nutrient levels]
GO:0031999 [negative regulation of fatty acid beta-oxidation]
GO:0043086 [negative regulation of catalytic activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046322 [negative regulation of fatty acid oxidation]
GO:0046872 [metal ion binding]
GO:0050995 [negative regulation of lipid catabolic process]
GO:0051289 [protein homotetramerization]
GO:0060421 [positive regulation of heart growth]
GO:0097009 [energy homeostasis]
GO:2001295 [malonyl-CoA biosynthetic process]
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 2458 aa
276.5 kDa 		Yes 0
ACACB-002
ENSP00000474680
ENST00000544726
S4R3S7 [Direct mapping]
Acetyl-CoA carboxylase 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004075 [biotin carboxylase activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
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 155 aa
17.6 kDa 		No 0
ACACB-005
ENSP00000443494
ENST00000539864
F5H5C3 [Direct mapping]
Acetyl-CoA carboxylase 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 143 aa
15.1 kDa 		No 0
ACACB-201
ENSP00000367079
ENST00000377848
O00763 [Direct mapping]
Acetyl-CoA carboxylase 2 Biotin carboxylase
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Enzymes
   ENZYME proteins
   Ligase
   MEMSAT-SVM predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003989 [acetyl-CoA carboxylase activity]
GO:0004075 [biotin carboxylase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006084 [acetyl-CoA metabolic process]
GO:0006112 [energy reserve metabolic process]
GO:0006633 [fatty acid biosynthetic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006768 [biotin metabolic process]
GO:0006853 [carnitine shuttle]
GO:0012505 [endomembrane system]
GO:0016874 [ligase activity]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0051289 [protein homotetramerization]
GO:2001295 [malonyl-CoA biosynthetic process]
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 2458 aa
276.5 kDa 		Yes 0
ACACB-202
ENSP00000367085
ENST00000377854
F8W8T8 [Direct mapping]
Acetyl-CoA carboxylase 2
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003989 [acetyl-CoA carboxylase activity]
GO:0005524 [ATP binding]
GO:0006633 [fatty acid biosynthetic process]
GO:0016874 [ligase activity]
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 858 aa
97.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.