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PAG1

GENERAL INFORMATION

Gene name

 PAG1

Gene description

 Phosphoprotein membrane anchor with glycosphingolipid microdomains 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (Daudi, HMC-1, SK-MEL-30)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in a few tissues, mainly in bone marrow and spleen.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA001632
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and testis cancer (unfavourable).
Renal cancer p<0.001
Testis cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001632

GENE INFORMATION

Gene name

 PAG1 (HGNC Symbol)

Synonyms

 CBP, PAG

Description

 Phosphoprotein membrane anchor with glycosphingolipid microdomains 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q21.13

Chromosome location (bp)

 80967810 - 81112068

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000076641 (version 83.38)

Entrez gene

 55824

UniProt

 Q9NWQ8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NWQ8

Antibodypedia

 PAG1 antibodies

PROTEIN BROWSER
PAG1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PAG1-001
ENSP00000220597
ENST00000220597
Q9NWQ8 [Direct mapping]
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002250 [adaptive immune response]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0016021 [integral component of membrane]
GO:0035556 [intracellular signal transduction]
GO:0042169 [SH2 domain binding]
GO:0045121 [membrane raft]
GO:0050852 [T cell receptor signaling pathway]
GO:0050863 [regulation of T cell activation]
GO:0050868 [negative regulation of T cell activation]
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 432 aa
47 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.