Expression of ICAM3 in cancer - Summary

GENERAL INFORMATION
Gene name	ICAM3
Gene description	Intercellular adhesion molecule 3
Protein class	CD markers Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (Karpas-707, RPMI-8226)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in subsets of hematopoietic cells and immune cells in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 1 antibody. CAB002498
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

CAB002498

GENE INFORMATION
Gene name	ICAM3 (HGNC Symbol)
Synonyms	CD50, CDW50, ICAM-R
Description	Intercellular adhesion molecule 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	10333776 - 10339823
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000076662 (version 83.38)
Entrez gene	3385
UniProt	P32942 (UniProt - Evidence at protein level)
neXtProt	NX_P32942
Antibodypedia	ICAM3 antibodies

PROTEIN BROWSER

ICAM3-001	ICAM3-005	ICAM3-006	ICAM3-007	ICAM3-008	ICAM3-009	ICAM3-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ICAM3-001 ENSP00000160262 ENST00000160262	P32942 [Direct mapping] Intercellular adhesion molecule 3 A0A024R7C1 [Target identity:100%; Query identity:100%] HCG2033729, isoform CRA_a Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0005102 [receptor binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0016337 [single organismal cell-cell adhesion] GO:0030198 [extracellular matrix organization] GO:0045087 [innate immune response] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] Show all	547 aa 59.5 kDa	Yes	1
ICAM3-005 ENSP00000468333 ENST00000589261	K7ERN2 [Direct mapping] Intercellular adhesion molecule 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0016337 [single organismal cell-cell adhesion] Show all	470 aa 51.4 kDa	No	1
ICAM3-006 ENSP00000466081 ENST00000589249	K7ELH4 [Direct mapping] Intercellular adhesion molecule 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] Show all	40 aa 4.3 kDa	No	0
ICAM3-007 ENSP00000468282 ENST00000589580	K7ERJ4 [Direct mapping] Intercellular adhesion molecule 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007155 [cell adhesion] Show all	23 aa 2.5 kDa	No	0
ICAM3-008 ENSP00000467770 ENST00000590569	K7EQC7 [Direct mapping] Intercellular adhesion molecule 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0016020 [membrane] GO:0016337 [single organismal cell-cell adhesion] Show all	133 aa 14.7 kDa	No	0
ICAM3-009 ENSP00000468230 ENST00000592945	K7ERF0 [Direct mapping] Intercellular adhesion molecule 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] Show all	192 aa 21.1 kDa	No	1
ICAM3-011 ENSP00000467232 ENST00000592439	K7EP52 [Direct mapping] Intercellular adhesion molecule 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] Show all	302 aa 32.6 kDa	No	1