Expression of CTTNBP2 in cancer - Summary - The Human Protein Atlas

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CTTNBP2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CTTNBP2
Gene description	Cortactin binding protein 2
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (HEL, HMC-1)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression, including neurons.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA044654 , CAB009151
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044654	CAB009151

GENE INFORMATION
Gene name	CTTNBP2 (HGNC Symbol)
Synonyms	C7orf8, CORTBP2, KIAA1758, Orf4
Description	Cortactin binding protein 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q31.31
Chromosome location (bp)	117710651 - 117874139
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000077063 (version 83.38)
Entrez gene	83992
UniProt	Q8WZ74 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WZ74
Antibodypedia	CTTNBP2 antibodies

PROTEIN BROWSER

CTTNBP2-001	CTTNBP2-002	CTTNBP2-004	CTTNBP2-006	CTTNBP2-007	CTTNBP2-009	CTTNBP2-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CTTNBP2-001 ENSP00000160373 ENST00000160373	Q8WZ74 [Direct mapping] Cortactin-binding protein 2 Q20BG9 [Target identity:100%; Query identity:100%] CTTNBP2; Cortactin binding protein 2; Cortactin binding protein 2, isoform CRA_b Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005938 [cell cortex] GO:0007420 [brain development] GO:0008021 [synaptic vesicle] GO:0017124 [SH3 domain binding] GO:0043197 [dendritic spine] Show all	1663 aa 181.1 kDa	No	0
CTTNBP2-002 ENSP00000396014 ENST00000434890	C9JFC9 [Direct mapping] Cortactin-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		161 aa 18.6 kDa	No	0
CTTNBP2-004 ENSP00000406142 ENST00000416239	H7C2I0 [Direct mapping] Cortactin-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		120 aa 13.4 kDa	No	0
CTTNBP2-006 ENSP00000405831 ENST00000454375	C9J720 [Direct mapping] Cortactin-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		136 aa 15.7 kDa	No	0
CTTNBP2-007 ENSP00000393373 ENST00000412853	C9JVQ6 [Direct mapping] Cortactin-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		95 aa 10.9 kDa	No	0
CTTNBP2-009 ENSP00000395925 ENST00000435233	H7C0N3 [Direct mapping] Cortactin-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		193 aa 21.4 kDa	No	0
CTTNBP2-011 ENSP00000389576 ENST00000446636	H0Y448 [Direct mapping] Cortactin-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1151 aa 125.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.