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PPP1R12B

GENERAL INFORMATION

Gene name

 PPP1R12B

Gene description

 Protein phosphatase 1, regulatory subunit 12B

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective expression in skeletal, cardiac and smooth muscle tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 2 antibodies.
HPA024171 , HPA024640
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA024171
HPA024640

GENE INFORMATION

Gene name

 PPP1R12B (HGNC Symbol)

Synonyms

 MGC131980, MGC87886, MYPT2, PP1bp55

Description

 Protein phosphatase 1, regulatory subunit 12B (HGNC Symbol)

Entrez gene summary

 Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome. [provided by RefSeq, Oct 2011]

Chromosome

 1

Cytoband

 q32.1

Chromosome location (bp)

 202348699 - 202592706

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000077157 (version 83.38)

Entrez gene

 4660

UniProt

 O60237 (UniProt - Evidence at protein level)

neXtProt

 NX_O60237

Antibodypedia

 PPP1R12B antibodies

PROTEIN BROWSER
PPP1R12B-001
PPP1R12B-002
PPP1R12B-003
PPP1R12B-005
PPP1R12B-011
PPP1R12B-013
PPP1R12B-020
PPP1R12B-021

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPP1R12B-001
ENSP00000476755
ENST00000608999
O60237 [Direct mapping]
Protein phosphatase 1 regulatory subunit 12B
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006937 [regulation of muscle contraction]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008047 [enzyme activator activity]
GO:0019208 [phosphatase regulator activity]
GO:0030018 [Z disc]
GO:0031672 [A band]
GO:0043085 [positive regulation of catalytic activity]
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 982 aa
110.4 kDa 		No 0
PPP1R12B-002
ENSP00000484005
ENST00000290419
O60237 [Direct mapping]
Protein phosphatase 1 regulatory subunit 12B
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006937 [regulation of muscle contraction]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008047 [enzyme activator activity]
GO:0019208 [phosphatase regulator activity]
GO:0030018 [Z disc]
GO:0031672 [A band]
GO:0043085 [positive regulation of catalytic activity]
Show all
 224 aa
26.3 kDa 		No 0
PPP1R12B-003
ENSP00000480852
ENST00000491336
O60237 [Direct mapping]
Protein phosphatase 1 regulatory subunit 12B
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006937 [regulation of muscle contraction]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008047 [enzyme activator activity]
GO:0019208 [phosphatase regulator activity]
GO:0030018 [Z disc]
GO:0031672 [A band]
GO:0043085 [positive regulation of catalytic activity]
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 208 aa
24.3 kDa 		No 0
PPP1R12B-005
ENSP00000349206
ENST00000356764
O60237 [Direct mapping]
Protein phosphatase 1 regulatory subunit 12B
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006937 [regulation of muscle contraction]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008047 [enzyme activator activity]
GO:0019208 [phosphatase regulator activity]
GO:0030018 [Z disc]
GO:0031672 [A band]
GO:0043085 [positive regulation of catalytic activity]
Show all
 386 aa
43.3 kDa 		No 0
PPP1R12B-011
ENSP00000417159
ENST00000480184
O60237 [Direct mapping]
Protein phosphatase 1 regulatory subunit 12B
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006937 [regulation of muscle contraction]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008047 [enzyme activator activity]
GO:0019208 [phosphatase regulator activity]
GO:0030018 [Z disc]
GO:0031672 [A band]
GO:0043085 [positive regulation of catalytic activity]
Show all
 515 aa
57.5 kDa 		No 0
PPP1R12B-013
ENSP00000417975
ENST00000466968
H7C4R6 [Direct mapping]
Protein phosphatase 1 regulatory subunit 12B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 212 aa
23.5 kDa 		No 0
PPP1R12B-020
ENSP00000488930
ENST00000634903
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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 186 aa
21.4 kDa 		No 0
PPP1R12B-021
ENSP00000375821
ENST00000391959
E1CKY7 [Direct mapping]
Protein phosphatase 1 regulatory subunit 12B; Smooth muscle type of myosin light chain phosphatase small subunit
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0019208 [phosphatase regulator activity]
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 1043 aa
116.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.