Expression of IL4R in cancer - Summary - The Human Protein Atlas

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IL4R

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IL4R
Gene description	Interleukin 4 receptor
Protein class	Cancer-related genes CD markers Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in immune cells in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA050124 , CAB004451
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and endometrial cancer (favourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA050124	CAB004451

GENE INFORMATION
Gene name	IL4R (HGNC Symbol)
Synonyms	CD124
Description	Interleukin 4 receptor (HGNC Symbol)
Entrez gene summary	This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
Chromosome	16
Cytoband	p12.1
Chromosome location (bp)	27313668 - 27364778
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000077238 (version 83.38)
Entrez gene	3566
UniProt	P24394 (UniProt - Evidence at protein level)
neXtProt	NX_P24394
Antibodypedia	IL4R antibodies

PROTEIN BROWSER

IL4R-001	IL4R-004	IL4R-005	IL4R-006	IL4R-007	IL4R-009	IL4R-012	IL4R-017	IL4R-018	IL4R-201	IL4R-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL4R-001 ENSP00000379111 ENST00000395762	P24394 [Direct mapping] Interleukin-4 receptor subunit alpha Soluble interleukin-4 receptor subunit alpha Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Show all	GO:0002532 [production of molecular mediator involved in inflammatory response] GO:0002639 [positive regulation of immunoglobulin production] GO:0004896 [cytokine receptor activity] GO:0004913 [interleukin-4 receptor activity] GO:0005057 [receptor signaling protein activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016064 [immunoglobulin mediated immune response] GO:0030728 [ovulation] GO:0035556 [intracellular signal transduction] GO:0035771 [interleukin-4-mediated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042832 [defense response to protozoan] GO:0043032 [positive regulation of macrophage activation] GO:0043235 [receptor complex] GO:0043306 [positive regulation of mast cell degranulation] GO:0043627 [response to estrogen] GO:0045626 [negative regulation of T-helper 1 cell differentiation] GO:0045630 [positive regulation of T-helper 2 cell differentiation] GO:0090197 [positive regulation of chemokine secretion] GO:1901741 [positive regulation of myoblast fusion] Show all	825 aa 89.7 kDa	Yes	1
IL4R-004 ENSP00000441667 ENST00000543915	P24394 [Direct mapping] Interleukin-4 receptor subunit alpha Soluble interleukin-4 receptor subunit alpha Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0002532 [production of molecular mediator involved in inflammatory response] GO:0004896 [cytokine receptor activity] GO:0004913 [interleukin-4 receptor activity] GO:0005057 [receptor signaling protein activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035556 [intracellular signal transduction] GO:0035771 [interleukin-4-mediated signaling pathway] GO:0043235 [receptor complex] Show all	825 aa 89.7 kDa	Yes	1
IL4R-005 ENSP00000455632 ENST00000566117	J9JII2 [Direct mapping] Interleukin-4 receptor subunit alpha Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0002532 [production of molecular mediator involved in inflammatory response] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] Show all	120 aa 13.2 kDa	Yes	0
IL4R-006 ENSP00000454725 ENST00000561742	A0A0G2JLA1 [Direct mapping] Interleukin-4 receptor subunit alpha Show all	Predicted intracellular proteins Show all		10 aa 1.1 kDa	No	0
IL4R-007 ENSP00000456930 ENST00000563002	J9JII2 [Direct mapping] Interleukin-4 receptor subunit alpha Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0002532 [production of molecular mediator involved in inflammatory response] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] Show all	120 aa 13.2 kDa	Yes	0
IL4R-009 ENSP00000457131 ENST00000562142	H3BTD9 [Direct mapping] Interleukin-4 receptor subunit alpha Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0002532 [production of molecular mediator involved in inflammatory response] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] Show all	64 aa 7.1 kDa	Yes	0
IL4R-012 ENSP00000456669 ENST00000562968	H3BSE7 [Direct mapping] Interleukin-4 receptor subunit alpha Show all	Predicted intracellular proteins Show all	GO:0002532 [production of molecular mediator involved in inflammatory response] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] Show all	49 aa 5.5 kDa	No	0
IL4R-017 ENSP00000461268 ENST00000565352	I3L4H7 [Direct mapping] Interleukin-4 receptor subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	133 aa 15.1 kDa	No	1
IL4R-018 ENSP00000461607 ENST00000565179	I3L4W9 [Direct mapping] Interleukin-4 receptor subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004896 [cytokine receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] Show all	193 aa 22 kDa	No	1
IL4R-201 ENSP00000170630 ENST00000170630	P24394 [Direct mapping] Interleukin-4 receptor subunit alpha Soluble interleukin-4 receptor subunit alpha Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0002532 [production of molecular mediator involved in inflammatory response] GO:0004896 [cytokine receptor activity] GO:0004913 [interleukin-4 receptor activity] GO:0005057 [receptor signaling protein activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035556 [intracellular signal transduction] GO:0035771 [interleukin-4-mediated signaling pathway] GO:0043235 [receptor complex] Show all	810 aa 88.3 kDa	No	1
IL4R-202 ENSP00000486645 ENST00000628578	Q5FC08 [Direct mapping] IL4R nirs variant 1; Interleukin-4 receptor subunit alpha Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		66 aa 7.3 kDa	Yes	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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