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SPAG6

GENERAL INFORMATION

Gene name

 SPAG6

Gene description

 Sperm associated antigen 6

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (fallopian tube, testis)
GTEx:Group enriched (pituitary gland, testis)
FANTOM5:Group enriched (pituitary gland, testis)

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in cilia in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Protein expression in respiratory epithelia can be correlated with lung RNA-seq data.

Reliability score

 Supported based on 1 antibody.
HPA038440
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Fallopian tube

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (fallopian tube, testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (pituitary gland, testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (pituitary gland, testis)

GENE INFORMATION

Gene name

 SPAG6 (HGNC Symbol)

Synonyms

 CT141, pf16, Repro-SA-1

Description

 Sperm associated antigen 6 (HGNC Symbol)

Entrez gene summary

 The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Chromosome

 10

Cytoband

 p12.2

Chromosome location (bp)

 22345445 - 22454224

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000077327 (version 83.38)

Entrez gene

 9576

UniProt

 O75602 (UniProt - Evidence at transcript level)

neXtProt

 NX_O75602

Antibodypedia

 SPAG6 antibodies

PROTEIN BROWSER
SPAG6-004
SPAG6-005
SPAG6-006
SPAG6-007
SPAG6-201
SPAG6-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SPAG6-004
ENSP00000365811
ENST00000376624
O75602 [Direct mapping]
Sperm-associated antigen 6
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005874 [microtubule]
GO:0005930 [axoneme]
GO:0007286 [spermatid development]
GO:0015630 [microtubule cytoskeleton]
GO:0030030 [cell projection organization]
GO:0031514 [motile cilium]
Show all
 509 aa
55.5 kDa 		No 0
SPAG6-005
ENSP00000323599
ENST00000313311
O75602 [Direct mapping]
Sperm-associated antigen 6
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005874 [microtubule]
GO:0005930 [axoneme]
GO:0007286 [spermatid development]
GO:0015630 [microtubule cytoskeleton]
GO:0030030 [cell projection organization]
GO:0031514 [motile cilium]
Show all
 458 aa
49.7 kDa 		No 0
SPAG6-006
ENSP00000411111
ENST00000456231
A0A0A0MT17 [Direct mapping]
Sperm-associated antigen 6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
Show all
 191 aa
21.1 kDa 		No 0
SPAG6-007
ENSP00000406594
ENST00000435326
A0A0A0MSY0 [Direct mapping]
Sperm-associated antigen 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
Show all
 246 aa
26.7 kDa 		No 0
SPAG6-201
ENSP00000365788
ENST00000376603
A0A0A0MRT8 [Direct mapping]
Sperm-associated antigen 6
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
Show all
 484 aa
52.4 kDa 		No 0
SPAG6-202
ENSP00000441325
ENST00000538630
O75602 [Direct mapping]
Sperm-associated antigen 6
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005874 [microtubule]
GO:0005930 [axoneme]
GO:0007286 [spermatid development]
GO:0015630 [microtubule cytoskeleton]
GO:0030030 [cell projection organization]
GO:0031514 [motile cilium]
Show all
 484 aa
52.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.