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DYNC1I2

GENERAL INFORMATION

Gene name

 DYNC1I2

Gene description

 Dynein, cytoplasmic 1, intermediate chain 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 19
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 3 antibodies.
HPA040619 , HPA053987 , CAB033836
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040619
HPA053987
CAB033836

GENE INFORMATION

Gene name

 DYNC1I2 (HGNC Symbol)

Synonyms

 DNCI2

Description

 Dynein, cytoplasmic 1, intermediate chain 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the dynein intermediate chain family. The encoded protein is a non-catalytic component of the cytoplasmic dynein 1 complex, which acts as a retrograde microtubule motor to transport organelles and vesicles. A pseudogene of this gene is located on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Chromosome

 2

Cytoband

 q31.1

Chromosome location (bp)

 171687409 - 171748420

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000077380 (version 83.38)

Entrez gene

 1781

UniProt

 Q13409 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13409

Antibodypedia

 DYNC1I2 antibodies

PROTEIN BROWSER
«
DYNC1I2-001
DYNC1I2-002
DYNC1I2-003
DYNC1I2-004
DYNC1I2-005
DYNC1I2-006
DYNC1I2-011
DYNC1I2-012
DYNC1I2-013
DYNC1I2-014
DYNC1I2-015
DYNC1I2-016
DYNC1I2-017
DYNC1I2-018
DYNC1I2-019
DYNC1I2-020
DYNC1I2-021
DYNC1I2-026
DYNC1I2-027
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DYNC1I2-001
ENSP00000380308
ENST00000397119
Q13409 [Direct mapping]
Cytoplasmic dynein 1 intermediate chain 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005868 [cytoplasmic dynein complex]
GO:0005874 [microtubule]
GO:0006810 [transport]
GO:0006996 [organelle organization]
GO:0007018 [microtubule-based movement]
GO:0008152 [metabolic process]
GO:0016032 [viral process]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0031982 [vesicle]
GO:0032403 [protein complex binding]
Show all
 638 aa
71.5 kDa 		No 0
DYNC1I2-002
ENSP00000339430
ENST00000340296
Q13409 [Direct mapping]
Cytoplasmic dynein 1 intermediate chain 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005868 [cytoplasmic dynein complex]
GO:0005874 [microtubule]
GO:0006810 [transport]
GO:0006996 [organelle organization]
GO:0007018 [microtubule-based movement]
GO:0008152 [metabolic process]
GO:0016032 [viral process]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0031982 [vesicle]
Show all
 612 aa
68.4 kDa 		No 0
DYNC1I2-003
ENSP00000386522
ENST00000410079
Q13409 [Direct mapping]
Cytoplasmic dynein 1 intermediate chain 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005868 [cytoplasmic dynein complex]
GO:0005874 [microtubule]
GO:0006810 [transport]
GO:0006996 [organelle organization]
GO:0007018 [microtubule-based movement]
GO:0008152 [metabolic process]
GO:0016032 [viral process]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0031982 [vesicle]
Show all
 630 aa
70.5 kDa 		No 0
DYNC1I2-004
ENSP00000386415
ENST00000409773
Q13409 [Direct mapping]
Cytoplasmic dynein 1 intermediate chain 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005868 [cytoplasmic dynein complex]
GO:0005874 [microtubule]
GO:0006810 [transport]
GO:0006996 [organelle organization]
GO:0007018 [microtubule-based movement]
GO:0008152 [metabolic process]
GO:0016032 [viral process]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0031982 [vesicle]
Show all
 638 aa
71.5 kDa 		No 0
DYNC1I2-005
ENSP00000386591
ENST00000409317
Q13409 [Direct mapping]
Cytoplasmic dynein 1 intermediate chain 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005868 [cytoplasmic dynein complex]
GO:0005874 [microtubule]
GO:0006810 [transport]
GO:0006996 [organelle organization]
GO:0007018 [microtubule-based movement]
GO:0008152 [metabolic process]
GO:0016032 [viral process]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0031982 [vesicle]
Show all
 632 aa
70.6 kDa 		No 0
DYNC1I2-006
ENSP00000386397
ENST00000409197
Q13409 [Direct mapping]
Cytoplasmic dynein 1 intermediate chain 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005868 [cytoplasmic dynein complex]
GO:0005874 [microtubule]
GO:0006810 [transport]
GO:0006996 [organelle organization]
GO:0007018 [microtubule-based movement]
GO:0008152 [metabolic process]
GO:0016032 [viral process]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0031982 [vesicle]
Show all
 612 aa
68.4 kDa 		No 0
DYNC1I2-011
ENSP00000392741
ENST00000438879
E7EMU4 [Direct mapping]
Cytoplasmic dynein 1 intermediate chain 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005868 [cytoplasmic dynein complex]
GO:0007018 [microtubule-based movement]
Show all
 214 aa
24 kDa 		No 0
DYNC1I2-012
ENSP00000388699
ENST00000456808
E7ESD3 [Direct mapping]
Cytoplasmic dynein 1 intermediate chain 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005868 [cytoplasmic dynein complex]
GO:0007018 [microtubule-based movement]
Show all
 187 aa
21 kDa 		No 0
DYNC1I2-013
ENSP00000410807
ENST00000435234
E7EQL5 [Direct mapping]
Cytoplasmic dynein 1 intermediate chain 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005868 [cytoplasmic dynein complex]
GO:0007018 [microtubule-based movement]
Show all
 305 aa
34.9 kDa 		No 0
DYNC1I2-014
ENSP00000401005
ENST00000443458
E7ERR6 [Direct mapping]
Cytoplasmic dynein 1 intermediate chain 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 139 aa
15.5 kDa 		No 0
DYNC1I2-015
ENSP00000406104
ENST00000412370
E7EUM4 [Direct mapping]
Cytoplasmic dynein 1 intermediate chain 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 137 aa
15.2 kDa 		No 0
DYNC1I2-016
ENSP00000397654
ENST00000423910
E7ET01 [Direct mapping]
Cytoplasmic dynein 1 intermediate chain 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005868 [cytoplasmic dynein complex]
GO:0007018 [microtubule-based movement]
Show all
 173 aa
19.3 kDa 		No 0
DYNC1I2-017
ENSP00000409951
ENST00000430778
E9PGG1 [Direct mapping]
Cytoplasmic dynein 1 intermediate chain 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 110 aa
12.3 kDa 		No 0
DYNC1I2-018
ENSP00000394492
ENST00000425485
E7EQU2 [Direct mapping]
Cytoplasmic dynein 1 intermediate chain 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005868 [cytoplasmic dynein complex]
GO:0007018 [microtubule-based movement]
Show all
 185 aa
20.8 kDa 		No 0
DYNC1I2-019
ENSP00000403089
ENST00000422646
E7ETL8 [Direct mapping]
Cytoplasmic dynein 1 intermediate chain 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005868 [cytoplasmic dynein complex]
GO:0007018 [microtubule-based movement]
Show all
 184 aa
20.6 kDa 		No 0
DYNC1I2-020
ENSP00000405454
ENST00000411953
E7ERH4 [Direct mapping]
Cytoplasmic dynein 1 intermediate chain 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 151 aa
16.8 kDa 		No 0
DYNC1I2-021
ENSP00000398765
ENST00000452242
E7EV09 [Direct mapping]
Cytoplasmic dynein 1 intermediate chain 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005868 [cytoplasmic dynein complex]
GO:0007018 [microtubule-based movement]
Show all
 251 aa
28.5 kDa 		No 0
DYNC1I2-026
ENSP00000423339
ENST00000508530
Q13409 [Direct mapping]
Cytoplasmic dynein 1 intermediate chain 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005868 [cytoplasmic dynein complex]
GO:0005874 [microtubule]
GO:0006810 [transport]
GO:0006996 [organelle organization]
GO:0007018 [microtubule-based movement]
GO:0008152 [metabolic process]
GO:0016032 [viral process]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0031982 [vesicle]
Show all
 611 aa
68.3 kDa 		No 0
DYNC1I2-027
ENSP00000386886
ENST00000409453
Q13409 [Direct mapping]
Cytoplasmic dynein 1 intermediate chain 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005868 [cytoplasmic dynein complex]
GO:0005874 [microtubule]
GO:0006810 [transport]
GO:0006996 [organelle organization]
GO:0007018 [microtubule-based movement]
GO:0008152 [metabolic process]
GO:0016032 [viral process]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0031982 [vesicle]
Show all
 637 aa
71.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.