Expression of LRCH4 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

LRCH4

premium

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LRCH4
Gene description	Leucine-rich repeats and calponin homology (CH) domain containing 4
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in a most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA037667 , HPA037668
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable).
Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA037667	HPA037668

GENE INFORMATION
Gene name	LRCH4 (HGNC Symbol)
Synonyms	LRN, LRRN1
Description	Leucine-rich repeats and calponin homology (CH) domain containing 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that contains leucine-rich repeats (LRR) at its amino terminus and that is known to be involved in ligand binding. The carboxyl terminus may act as a membrane anchor. Identified structural elements suggest that the encoded protein resembles a receptor. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	100574011 - 100586153
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000077454 (version 83.38)
Entrez gene	4034
UniProt	O75427 (UniProt - Evidence at protein level)
neXtProt	NX_O75427
Antibodypedia	LRCH4 antibodies

PROTEIN BROWSER

LRCH4-001	LRCH4-002	LRCH4-012	LRCH4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRCH4-001 ENSP00000309689 ENST00000310300	O75427 [Direct mapping] Leucine-rich repeat and calponin homology domain-containing protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007399 [nervous system development] GO:0016605 [PML body] Show all	683 aa 73.4 kDa	Yes	1
LRCH4-002 ENSP00000419870 ENST00000497245	C9JYK0 [Direct mapping] Leucine-rich repeat and calponin homology domain-containing protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	231 aa 24.4 kDa	No	1
LRCH4-012 ENSP00000419674 ENST00000485554	H7C5D9 [Direct mapping] Leucine-rich repeat and calponin homology domain-containing protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	177 aa 19 kDa	No	0
LRCH4-201 ENSP00000483999 ENST00000619071	A0A087X197 [Direct mapping] Leucine-rich repeat and calponin homology domain-containing protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	142 aa 15.7 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.