Expression of FAM76B in cancer - Summary - The Human Protein Atlas

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FAM76B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FAM76B
Gene description	Family with sequence similarity 76, member B
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in germinal center cells of lymphoid tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA036608
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and urothelial cancer (favourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036608

GENE INFORMATION
Gene name	FAM76B (HGNC Symbol)
Synonyms	MGC33371
Description	Family with sequence similarity 76, member B (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q21
Chromosome location (bp)	95768942 - 95790409
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000077458 (version 83.38)
Entrez gene	143684
UniProt	Q5HYJ3 (UniProt - Evidence at protein level)
neXtProt	NX_Q5HYJ3
Antibodypedia	FAM76B antibodies

PROTEIN BROWSER

FAM76B-002	FAM76B-005	FAM76B-006	FAM76B-007	FAM76B-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM76B-002 ENSP00000351631 ENST00000358780	Q5HYJ3 [Direct mapping] Protein FAM76B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000338 [protein deneddylation] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0016607 [nuclear speck] GO:0019784 [NEDD8-specific protease activity] GO:0031965 [nuclear membrane] Show all	339 aa 38.7 kDa	No	0
FAM76B-005 ENSP00000441168 ENST00000536839	F5GX09 [Direct mapping] Protein FAM76B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000338 [protein deneddylation] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0019784 [NEDD8-specific protease activity] GO:0031965 [nuclear membrane] Show all	338 aa 38.6 kDa	No	0
FAM76B-006 ENSP00000442652 ENST00000540054	F5H215 [Direct mapping] Protein FAM76B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000338 [protein deneddylation] GO:0005737 [cytoplasm] GO:0016021 [integral component of membrane] GO:0019784 [NEDD8-specific protease activity] Show all	91 aa 10.7 kDa	No	1
FAM76B-007 ENSP00000445612 ENST00000542135	F5H215 [Direct mapping] Protein FAM76B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000338 [protein deneddylation] GO:0005737 [cytoplasm] GO:0016021 [integral component of membrane] GO:0019784 [NEDD8-specific protease activity] Show all	91 aa 10.7 kDa	No	1
FAM76B-010 ENSP00000437366 ENST00000537749	F5H6T9 [Direct mapping] Protein FAM76B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000338 [protein deneddylation] GO:0005737 [cytoplasm] GO:0019784 [NEDD8-specific protease activity] Show all	47 aa 5.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.