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Gene name

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Chromosome

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Reliability

Reliability

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Method

Validation

Method

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Searches

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Cancer

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Tissue

Detectable

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Antibodies

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TYR
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

TYR

Gene description

Tyrosinase

Protein class

Disease related genes
Enzymes
FDA approved drug targets
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (melanoma)
HPA (cell line):Cell line enriched (SK-MEL-30)
HPA (normal tissue):Tissue enriched (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in melanocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
CAB000079
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (melanoma)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY

CAB000079

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Melanomas displayed strong cytoplasmic immunoreactivity. Remaining cancer cells were negative.

GENE INFORMATION

Gene name

TYR (HGNC Symbol)

Synonyms

OCA1, OCA1A, OCAIA

Description

Tyrosinase (HGNC Symbol)

Entrez gene summary

The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008]

Chromosome

11

Cytoband

q14.3

Chromosome location (bp)

89177452 - 89295759

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000077498 (version 83.38)

Entrez gene

7299

UniProt

P14679 (UniProt - Evidence at protein level)

neXtProt

NX_P14679

Antibodypedia

TYR antibodies

PROTEIN BROWSER

TYR-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TYR-001
ENSP00000263321
ENST00000263321
P14679 [Direct mapping]
Tyrosinase
L8B082 [Target identity:100%; Query identity:100%]
Tyrosinase; Tyrosinase (Oculocutaneous albinism IA), isoform CRA_a
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
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GO:0004497 [monooxygenase activity]
GO:0004503 [monophenol monooxygenase activity]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005798 [Golgi-associated vesicle]
GO:0005829 [cytosol]
GO:0006583 [melanin biosynthetic process from tyrosine]
GO:0006726 [eye pigment biosynthetic process]
GO:0007601 [visual perception]
GO:0008152 [metabolic process]
GO:0008283 [cell proliferation]
GO:0009411 [response to UV]
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0033162 [melanosome membrane]
GO:0033280 [response to vitamin D]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042438 [melanin biosynthetic process]
GO:0042470 [melanosome]
GO:0042803 [protein homodimerization activity]
GO:0043473 [pigmentation]
GO:0044281 [small molecule metabolic process]
GO:0046982 [protein heterodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048538 [thymus development]
GO:0051591 [response to cAMP]
GO:0055114 [oxidation-reduction process]
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529 aa
60.4 kDa
Yes 1

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