We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Melanomas displayed strong cytoplasmic immunoreactivity. Remaining cancer cells were negative.
GENE INFORMATION
Gene name
TYR (HGNC Symbol)
Synonyms
OCA1, OCA1A, OCAIA
Description
Tyrosinase (HGNC Symbol)
Entrez gene summary
The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008]