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FGFR1

GENERAL INFORMATION

Gene name

 FGFR1

Gene description

 Fibroblast growth factor receptor 1

Protein class

 Cancer-related genes
CD markers
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 20
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (AN3-CA)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic, nuclear and membranous expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA056402 , CAB033614
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA056402
CAB033614

GENE INFORMATION

Gene name

 FGFR1 (HGNC Symbol)

Synonyms

 BFGFR, CD331, CEK, FLG, FLT2, H2, H3, H4, H5, KAL2, N-SAM

Description

 Fibroblast growth factor receptor 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 p11.23

Chromosome location (bp)

 38411138 - 38468834

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000077782 (version 83.38)

Entrez gene

 2260

UniProt

 P11362 (UniProt - Evidence at protein level)

neXtProt

 NX_P11362

Antibodypedia

 FGFR1 antibodies

PROTEIN BROWSER
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FGFR1-001
FGFR1-002
FGFR1-003
FGFR1-004
FGFR1-008
FGFR1-011
FGFR1-012
FGFR1-015
FGFR1-016
FGFR1-019
FGFR1-020
FGFR1-027
FGFR1-028
FGFR1-036
FGFR1-037
FGFR1-038
FGFR1-201
FGFR1-202
FGFR1-203
FGFR1-204
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FGFR1-001
ENSP00000380280
ENST00000397091
P11362 [Direct mapping]
Fibroblast growth factor receptor 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001501 [skeletal system development]
GO:0001764 [neuron migration]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010518 [positive regulation of phospholipase activity]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016477 [cell migration]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043009 [chordate embryonic development]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045087 [innate immune response]
GO:0045595 [regulation of cell differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048705 [skeletal system morphogenesis]
Show all
 820 aa
91.6 kDa 		Yes 1
FGFR1-002
ENSP00000432972
ENST00000532791
P11362 [Direct mapping]
Fibroblast growth factor receptor 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001501 [skeletal system development]
GO:0001764 [neuron migration]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010518 [positive regulation of phospholipase activity]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016477 [cell migration]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043009 [chordate embryonic development]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045087 [innate immune response]
GO:0045595 [regulation of cell differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048705 [skeletal system morphogenesis]
Show all
 820 aa
91.7 kDa 		Yes 1
FGFR1-003
ENSP00000337247
ENST00000335922
P11362 [Direct mapping]
Fibroblast growth factor receptor 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001501 [skeletal system development]
GO:0001764 [neuron migration]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010518 [positive regulation of phospholipase activity]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016477 [cell migration]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043009 [chordate embryonic development]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045087 [innate immune response]
GO:0045595 [regulation of cell differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048705 [skeletal system morphogenesis]
Show all
 812 aa
90.6 kDa 		No 1
FGFR1-004
ENSP00000348537
ENST00000356207
P11362 [Direct mapping]
Fibroblast growth factor receptor 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001501 [skeletal system development]
GO:0001764 [neuron migration]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010518 [positive regulation of phospholipase activity]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016477 [cell migration]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043009 [chordate embryonic development]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045087 [innate immune response]
GO:0045595 [regulation of cell differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048705 [skeletal system morphogenesis]
Show all
 733 aa
82.2 kDa 		Yes 1
FGFR1-008
ENSP00000327229
ENST00000326324
P11362 [Direct mapping]
Fibroblast growth factor receptor 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001501 [skeletal system development]
GO:0001764 [neuron migration]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010518 [positive regulation of phospholipase activity]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016477 [cell migration]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043009 [chordate embryonic development]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045087 [innate immune response]
GO:0045595 [regulation of cell differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048705 [skeletal system morphogenesis]
Show all
 731 aa
81.9 kDa 		Yes 1
FGFR1-011
ENSP00000380292
ENST00000397103
E7EU09 [Direct mapping]
Fibroblast growth factor receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 733 aa
82 kDa 		Yes 1
FGFR1-012
ENSP00000380302
ENST00000397113
P11362 [Direct mapping]
Fibroblast growth factor receptor 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001501 [skeletal system development]
GO:0001764 [neuron migration]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010518 [positive regulation of phospholipase activity]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016477 [cell migration]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043009 [chordate embryonic development]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045087 [innate immune response]
GO:0045595 [regulation of cell differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048705 [skeletal system morphogenesis]
Show all
 820 aa
91.6 kDa 		Yes 1
FGFR1-015
ENSP00000400708
ENST00000413133
C9J205 [Direct mapping]
Fibroblast growth factor receptor 1
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
Show all
 107 aa
11.9 kDa 		Yes 0
FGFR1-016
ENSP00000392645
ENST00000434187
C9J1L5 [Direct mapping]
Fibroblast growth factor receptor 1
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 55 aa
6.2 kDa 		Yes 0
FGFR1-019
ENSP00000398318
ENST00000440174
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 1 aa
0.1 kDa 		No 0
FGFR1-020
ENSP00000380297
ENST00000397108
P11362 [Direct mapping]
Fibroblast growth factor receptor 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001501 [skeletal system development]
GO:0001764 [neuron migration]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010518 [positive regulation of phospholipase activity]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016477 [cell migration]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043009 [chordate embryonic development]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045087 [innate immune response]
GO:0045595 [regulation of cell differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048705 [skeletal system morphogenesis]
Show all
 820 aa
91.6 kDa 		Yes 1
FGFR1-027
ENSP00000434473
ENST00000530568
E9PQ40 [Direct mapping]
Fibroblast growth factor receptor 1
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
Show all
 85 aa
9.5 kDa 		Yes 0
FGFR1-028
ENSP00000434869
ENST00000533668
E9PN14 [Direct mapping]
Fibroblast growth factor receptor 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
Show all
 139 aa
15.7 kDa 		No 0
FGFR1-036
ENSP00000434712
ENST00000525001
E9PNM3 [Direct mapping]
Fibroblast growth factor receptor 1
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
Show all
 298 aa
33.3 kDa 		Yes 0
FGFR1-037
ENSP00000435283
ENST00000529552
E9PKV7 [Direct mapping]
Fibroblast growth factor receptor 1
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
Show all
 142 aa
16 kDa 		Yes 0
FGFR1-038
ENSP00000433569
ENST00000526742
E9PKF2 [Direct mapping]
Fibroblast growth factor receptor 1
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
Show all
 145 aa
16.4 kDa 		Yes 0
FGFR1-201
ENSP00000340636
ENST00000341462
C1KBH7 [Direct mapping]
Fibroblast growth factor receptor 1; Fibroblast growth factor receptor 1 isoform 3
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
Show all
 367 aa
40.7 kDa 		Yes 0
FGFR1-202
ENSP00000393312
ENST00000425967
P11362 [Direct mapping]
Fibroblast growth factor receptor 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001501 [skeletal system development]
GO:0001525 [angiogenesis]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0001759 [organ induction]
GO:0001764 [neuron migration]
GO:0001948 [glycoprotein binding]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0002062 [chondrocyte differentiation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007420 [brain development]
GO:0007435 [salivary gland morphogenesis]
GO:0007605 [sensory perception of sound]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010468 [regulation of gene expression]
GO:0010518 [positive regulation of phospholipase activity]
GO:0010629 [negative regulation of gene expression]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0010976 [positive regulation of neuron projection development]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016477 [cell migration]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019827 [stem cell population maintenance]
GO:0021769 [orbitofrontal cortex development]
GO:0021837 [motogenic signaling involved in postnatal olfactory bulb interneuron migration]
GO:0021847 [ventricular zone neuroblast division]
GO:0021954 [central nervous system neuron development]
GO:0030324 [lung development]
GO:0030326 [embryonic limb morphogenesis]
GO:0030901 [midbrain development]
GO:0031175 [neuron projection development]
GO:0032403 [protein complex binding]
GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042472 [inner ear morphogenesis]
GO:0042473 [outer ear morphogenesis]
GO:0042474 [middle ear morphogenesis]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043009 [chordate embryonic development]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045087 [innate immune response]
GO:0045595 [regulation of cell differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048339 [paraxial mesoderm development]
GO:0048378 [regulation of lateral mesodermal cell fate specification]
GO:0048469 [cell maturation]
GO:0048514 [blood vessel morphogenesis]
GO:0048699 [generation of neurons]
GO:0048705 [skeletal system morphogenesis]
GO:0048762 [mesenchymal cell differentiation]
GO:0050839 [cell adhesion molecule binding]
GO:0051930 [regulation of sensory perception of pain]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060117 [auditory receptor cell development]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060484 [lung-associated mesenchyme development]
GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling]
GO:0072091 [regulation of stem cell proliferation]
GO:0090080 [positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway]
GO:2001239 [regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 853 aa
95.3 kDa 		No 1
FGFR1-203
ENSP00000400162
ENST00000447712
P11362 [Direct mapping]
Fibroblast growth factor receptor 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001501 [skeletal system development]
GO:0001764 [neuron migration]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010518 [positive regulation of phospholipase activity]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016477 [cell migration]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043009 [chordate embryonic development]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045087 [innate immune response]
GO:0045595 [regulation of cell differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048705 [skeletal system morphogenesis]
Show all
 822 aa
91.9 kDa 		Yes 1
FGFR1-204
ENSP00000484553
ENST00000619564
B5A958 [Direct mapping]
Fibroblast growth factor receptor 1; Soluble FGFR1 variant 1
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
Show all
 228 aa
25.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.