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FKBP6

GENERAL INFORMATION

Gene name

 FKBP6

Gene description

 FK506 binding protein 6, 36kDa

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)
FANTOM5:Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Granular cytoplasmic expression in spermatogonia and ovarian follicle cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Nuclear staining observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA061109
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Ovary

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 FKBP6 (HGNC Symbol)

Synonyms

 FKBP36, PPIase

Description

 FK506 binding protein 6, 36kDa (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a cis-trans peptidyl-prolyl isomerase that may function in immunoregulation and basic cellular processes involving protein folding and trafficking. This gene is located in a chromosomal region that is deleted in Williams-Beuren syndrome. Defects in this gene may cause male infertility. There are multiple pseudogenes for this gene located nearby on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

 7

Cytoband

 q11.23

Chromosome location (bp)

 73328164 - 73358637

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000077800 (version 83.38)

Entrez gene

 8468

UniProt

 O75344 (UniProt - Evidence at protein level)

neXtProt

 NX_O75344

Antibodypedia

 FKBP6 antibodies

PROTEIN BROWSER
FKBP6-001
FKBP6-002
FKBP6-003
FKBP6-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FKBP6-001
ENSP00000252037
ENST00000252037
O75344 [Direct mapping]
Inactive peptidyl-prolyl cis-trans isomerase FKBP6
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0000795 [synaptonemal complex]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0007126 [meiotic nuclear division]
GO:0007283 [spermatogenesis]
GO:0018208 [peptidyl-proline modification]
GO:0030154 [cell differentiation]
GO:0031047 [gene silencing by RNA]
GO:0034587 [piRNA metabolic process]
GO:0043046 [DNA methylation involved in gamete generation]
GO:0051879 [Hsp90 protein binding]
GO:0061077 [chaperone-mediated protein folding]
Show all
 327 aa
37.2 kDa 		No 0
FKBP6-002
ENSP00000416277
ENST00000431982
O75344 [Direct mapping]
Inactive peptidyl-prolyl cis-trans isomerase FKBP6
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0000795 [synaptonemal complex]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0007126 [meiotic nuclear division]
GO:0007283 [spermatogenesis]
GO:0030154 [cell differentiation]
GO:0031047 [gene silencing by RNA]
GO:0034587 [piRNA metabolic process]
GO:0043046 [DNA methylation involved in gamete generation]
GO:0051879 [Hsp90 protein binding]
GO:0061077 [chaperone-mediated protein folding]
Show all
 322 aa
36.9 kDa 		No 0
FKBP6-003
ENSP00000394952
ENST00000413573
O75344 [Direct mapping]
Inactive peptidyl-prolyl cis-trans isomerase FKBP6
Show all
Predicted intracellular proteins
Disease related genes
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0000795 [synaptonemal complex]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0007126 [meiotic nuclear division]
GO:0007283 [spermatogenesis]
GO:0030154 [cell differentiation]
GO:0031047 [gene silencing by RNA]
GO:0034587 [piRNA metabolic process]
GO:0043046 [DNA methylation involved in gamete generation]
GO:0051879 [Hsp90 protein binding]
GO:0061077 [chaperone-mediated protein folding]
Show all
 297 aa
33.6 kDa 		No 0
FKBP6-006
ENSP00000402360
ENST00000442793
C9JM01 [Direct mapping]
Inactive peptidyl-prolyl cis-trans isomerase FKBP6
Show all
Predicted intracellular proteins
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0061077 [chaperone-mediated protein folding]
Show all
 252 aa
28.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.