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SMC1B

GENERAL INFORMATION

Gene name

 SMC1B

Gene description

 Structural maintenance of chromosomes 1B

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (cervical cancer)
HPA (cell line):Cell line enhanced (A-431, EFO-21, SiHa)
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective nuclear and cytoplasmic expression in seminiferous ducts of testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA001500
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (cervical cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001500

GENE INFORMATION

Gene name

 SMC1B (HGNC Symbol)

Synonyms

 bK268H5, SMC1L2

Description

 Structural maintenance of chromosomes 1B (HGNC Symbol)

Entrez gene summary

 SMC1L2 belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis (3:Revenkova et al., 2001 [PubMed 11564881]).[supplied by OMIM, Mar 2008]

Chromosome

 22

Cytoband

 q13.31

Chromosome location (bp)

 45344063 - 45413619

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000077935 (version 83.38)

Entrez gene

 27127

UniProt

 Q8NDV3 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8NDV3

Antibodypedia

 SMC1B antibodies

PROTEIN BROWSER
SMC1B-002
SMC1B-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SMC1B-002
ENSP00000385902
ENST00000404354
Q8NDV3 [Direct mapping]
Structural maintenance of chromosomes protein 1B
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Predicted intracellular proteins
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GO:0000775 [chromosome, centromeric region]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0030893 [meiotic cohesin complex]
GO:0051276 [chromosome organization]
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 1161 aa
135.8 kDa 		No 0
SMC1B-003
ENSP00000350036
ENST00000357450
Q8NDV3 [Direct mapping]
Structural maintenance of chromosomes protein 1B
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
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GO:0000775 [chromosome, centromeric region]
GO:0000794 [condensed nuclear chromosome]
GO:0000795 [synaptonemal complex]
GO:0000800 [lateral element]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0007062 [sister chromatid cohesion]
GO:0007126 [meiotic nuclear division]
GO:0030893 [meiotic cohesin complex]
GO:0034991 [nuclear meiotic cohesin complex]
GO:0051276 [chromosome organization]
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 1235 aa
143.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.