Cell atlas - LAMP3 - The Human Protein Atlas

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LAMP3

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus
	Vesicles

Human cell
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	LAMP3
Gene description	Lysosomal-associated membrane protein 3
Protein class	CD markers Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles. In addition localized to the nucleus.
RNA cell category	Group enriched (EFO-21, HDLM-2, hTCEpi)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported)
Additional location	In addition localized to the Nucleus (uncertain)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA051467
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (EFO-21, HDLM-2, hTCEpi) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles. In addition localized to the nucleus.

Main location

Vesicles (supported)

Additional location

Nucleus (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA051467	A-431	Nucleoplasm
	HPA051467	A-431	Vesicles
	HPA051467	HEK 293	Vesicles
	HPA051467	U-2 OS	Nucleus
	HPA051467	U-2 OS	Vesicles

GENE INFORMATION
Gene name	LAMP3 (HGNC Symbol)
Synonyms	CD208, DC-LAMP, DCLAMP, LAMP, TSC403
Description	Lysosomal-associated membrane protein 3 (HGNC Symbol)
Entrez gene summary	Dendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses (summary by de Saint-Vis et al., 1998 [PubMed 9768752]).[supplied by OMIM, Dec 2010]
Chromosome	3
Cytoband	q27.1
Chromosome location (bp)	183122213 - 183163839
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000078081 (version 83.38)
Entrez gene	27074
UniProt	Q9UQV4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UQV4
Antibodypedia	LAMP3 antibodies

PROTEIN BROWSER

LAMP3-001	LAMP3-002	LAMP3-003	LAMP3-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LAMP3-001 ENSP00000265598 ENST00000265598	Q9UQV4 [Direct mapping] Lysosome-associated membrane glycoprotein 3 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0008283 [cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0097233 [alveolar lamellar body membrane] Show all	416 aa 44.3 kDa	Yes	1
LAMP3-002 ENSP00000418912 ENST00000466939	E7ETP9 [Direct mapping] Lysosome-associated membrane glycoprotein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	392 aa 41.9 kDa	No	1
LAMP3-003 ENSP00000419059 ENST00000476015	C9JYP5 [Direct mapping] Lysosome-associated membrane glycoprotein 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] Show all	180 aa 18.8 kDa	Yes	0
LAMP3-005 ENSP00000420589 ENST00000470251	C9JDI8 [Direct mapping] Lysosome-associated membrane glycoprotein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] Show all	143 aa 15 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.