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ADCY2

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GENERAL INFORMATION

Gene name

 ADCY2

Gene description

 Adenylate cyclase 2 (brain)

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (AF22, NTERA-2, SK-MEL-30)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (AF22, NTERA-2, SK-MEL-30)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 ADCY2 (HGNC Symbol)

Synonyms

 AC2, HBAC2, KIAA1060

Description

 Adenylate cyclase 2 (brain) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 p15.31

Chromosome location (bp)

 7396208 - 7830081

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000078295 (version 83.38)

Entrez gene

 108

UniProt

 Q08462 (UniProt - Evidence at protein level)

neXtProt

 NX_Q08462

Antibodypedia

 ADCY2 antibodies

PROTEIN BROWSER
ADCY2-001
ADCY2-008
ADCY2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADCY2-001
ENSP00000342952
ENST00000338316
Q08462 [Direct mapping]
Adenylate cyclase type 2
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003091 [renal water homeostasis]
GO:0004016 [adenylate cyclase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006171 [cAMP biosynthetic process]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007268 [synaptic transmission]
GO:0008179 [adenylate cyclase binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016020 [membrane]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0019933 [cAMP-mediated signaling]
GO:0030145 [manganese ion binding]
GO:0030425 [dendrite]
GO:0034199 [activation of protein kinase A activity]
GO:0035556 [intracellular signal transduction]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0055085 [transmembrane transport]
GO:0071377 [cellular response to glucagon stimulus]
GO:1904322 [cellular response to forskolin]
Show all
 1091 aa
123.6 kDa 		No >9
ADCY2-008
ENSP00000425069
ENST00000515681
D6REB8 [Direct mapping]
Adenylate cyclase type 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0035556 [intracellular signal transduction]
Show all
 100 aa
11.5 kDa 		No 0
ADCY2-201
ENSP00000444803
ENST00000537121
A0A0A0MTM9 [Direct mapping]
Adenylate cyclase type 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004016 [adenylate cyclase activity]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006171 [cAMP biosynthetic process]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0035556 [intracellular signal transduction]
Show all
 1089 aa
123.4 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.