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GNB1

GENERAL INFORMATION

Gene name

 GNB1

Gene description

 Guanine nucleotide binding protein (G protein), beta polypeptide 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression at variable levels in several different tissue types, highly expressed in brain.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 1 antibody.
HPA040736
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GNB1

Synonyms

Description

 Guanine nucleotide binding protein (G protein), beta polypeptide 1 (HGNC Symbol)

Entrez gene summary

 Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Chromosome

 1

Cytoband

 p36.33

Chromosome location (bp)

 1785285 - 1891117

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000078369 (version 83.38)

Entrez gene

 2782

UniProt

 P62873 (UniProt - Evidence at protein level)

neXtProt

 NX_P62873

Antibodypedia

 GNB1 antibodies

PROTEIN BROWSER
GNB1-001
GNB1-005
GNB1-006
GNB1-007
GNB1-201
GNB1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GNB1-001
ENSP00000367872
ENST00000378609
P62873 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
A0A024R056 [Target identity:100%; Query identity:100%]
Guanine nucleotide binding protein (G protein), beta polypeptide 1, isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005765 [lysosomal membrane]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007165 [signal transduction]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007213 [G-protein coupled acetylcholine receptor signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0007603 [phototransduction, visible light]
GO:0016020 [membrane]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0030168 [platelet activation]
GO:0032403 [protein complex binding]
GO:0044281 [small molecule metabolic process]
GO:0051020 [GTPase binding]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071870 [cellular response to catecholamine stimulus]
GO:0097381 [photoreceptor disc membrane]
GO:1903561 [extracellular vesicle]
Show all
 340 aa
37.4 kDa 		No 0
GNB1-005
ENSP00000399741
ENST00000439272
F6X3N5 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
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Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
 163 aa
18.3 kDa 		No 0
GNB1-006
ENSP00000416651
ENST00000437146
B1AKQ8 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
 108 aa
12.3 kDa 		No 0
GNB1-007
ENSP00000392765
ENST00000434686
F6UT28 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
 165 aa
18.4 kDa 		No 0
GNB1-201
ENSP00000481878
ENST00000610897
P62873 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
A0A024R056 [Target identity:100%; Query identity:100%]
Guanine nucleotide binding protein (G protein), beta polypeptide 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0001750 [photoreceptor outer segment]
GO:0001917 [photoreceptor inner segment]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007213 [G-protein coupled acetylcholine receptor signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0007603 [phototransduction, visible light]
GO:0008283 [cell proliferation]
GO:0010659 [cardiac muscle cell apoptotic process]
GO:0016020 [membrane]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0030168 [platelet activation]
GO:0030425 [dendrite]
GO:0030507 [spectrin binding]
GO:0031702 [type 1 angiotensin receptor binding]
GO:0032403 [protein complex binding]
GO:0042622 [photoreceptor outer segment membrane]
GO:0043209 [myelin sheath]
GO:0044281 [small molecule metabolic process]
GO:0044297 [cell body]
GO:0050909 [sensory perception of taste]
GO:0051020 [GTPase binding]
GO:0060041 [retina development in camera-type eye]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071456 [cellular response to hypoxia]
GO:0071870 [cellular response to catecholamine stimulus]
GO:0097381 [photoreceptor disc membrane]
GO:1903561 [extracellular vesicle]
Show all
 340 aa
37.4 kDa 		No 0
GNB1-202
ENSP00000483532
ENST00000615252
B3KVK2 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; cDNA FLJ16663 fis, clone THYMU2005759, highly similar to Guanine nucleotide-binding proteinG(I)/G(S)/G(T) subunit beta 1
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Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
 240 aa
25.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.