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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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HOXA9
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

HOXA9

Gene description

Homeobox A9

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (HEK93, SCLC-21H)
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Uncertain based on 1 antibody.
HPA061982
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA061982

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer cells showed moderate nuclear positivity. Cases of renal cell carcinomas and carcinoids displayed strong staining. Additional cytoplasmic positivity was observed in several renal cell carcinomas and a few cases of colorectal, endometrial and liver cancers.

GENE INFORMATION

Gene name

HOXA9 (HGNC Symbol)

Synonyms

HOX1, HOX1G

Description

Homeobox A9 (HGNC Symbol)

Entrez gene summary

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.[provided by RefSeq, Mar 2011]

Chromosome

7

Cytoband

p15.2

Chromosome location (bp)

27162435 - 27175180

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000078399 (version 83.38)

Entrez gene

3205

UniProt

P31269 (UniProt - Evidence at protein level)

neXtProt

NX_P31269

Antibodypedia

HOXA9 antibodies

PROTEIN BROWSER

HOXA9-001
HOXA9-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HOXA9-001
ENSP00000343619
ENST00000343483
P31269 [Direct mapping]
Homeobox protein Hox-A9
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Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0007283 [spermatogenesis]
GO:0007338 [single fertilization]
GO:0008584 [male gonad development]
GO:0009952 [anterior/posterior pattern specification]
GO:0009954 [proximal/distal pattern formation]
GO:0010468 [regulation of gene expression]
GO:0019899 [enzyme binding]
GO:0030879 [mammary gland development]
GO:0035115 [embryonic forelimb morphogenesis]
GO:0042118 [endothelial cell activation]
GO:0043565 [sequence-specific DNA binding]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0048706 [embryonic skeletal system development]
GO:0060065 [uterus development]
GO:0060216 [definitive hemopoiesis]
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272 aa
30.2 kDa
No 0
HOXA9-003
ENSP00000379634
ENST00000396345
A8MVF3 [Direct mapping]
Homeobox protein Hox-A9
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Show all
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
Show all
106 aa
10.9 kDa
No 0

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