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Most cancer cells showed moderate nuclear positivity. Cases of renal cell carcinomas and carcinoids displayed strong staining. Additional cytoplasmic positivity was observed in several renal cell carcinomas and a few cases of colorectal, endometrial and liver cancers.
GENE INFORMATION
Gene name
HOXA9 (HGNC Symbol)
Synonyms
HOX1, HOX1G
Description
Homeobox A9 (HGNC Symbol)
Entrez gene summary
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.[provided by RefSeq, Mar 2011]