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FGF20

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GENERAL INFORMATION

Gene name

 FGF20

Gene description

 Fibroblast growth factor 20

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (CAPAN-2, BJ hTERT+)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CAPAN-2, BJ hTERT+)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 FGF20

Synonyms

Description

 Fibroblast growth factor 20 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009]

Chromosome

 8

Cytoband

 p22

Chromosome location (bp)

 16992169 - 17002181

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000078579 (version 83.38)

Entrez gene

 26281

UniProt

 Q9NP95 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NP95

Antibodypedia

 FGF20 antibodies

PROTEIN BROWSER
FGF20-001
FGF20-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FGF20-001
ENSP00000180166
ENST00000180166
Q9NP95 [Direct mapping]
Fibroblast growth factor 20
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0030154 [cell differentiation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0060043 [regulation of cardiac muscle cell proliferation]
GO:0060113 [inner ear receptor cell differentiation]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
Show all
 211 aa
23.5 kDa 		No 0
FGF20-002
ENSP00000428072
ENST00000519941
H0YAT9 [Direct mapping]
Fibroblast growth factor 20
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005576 [extracellular region]
GO:0008083 [growth factor activity]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
Show all
 113 aa
12.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.