Cell atlas - ITM2A - The Human Protein Atlas

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ITM2A

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ITM2A
Gene description	Integral membrane protein 2A
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Cell line enriched (MOLT-4)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA002918
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (MOLT-4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA002918	SH-SY5Y	Nucleoplasm
	HPA002918	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	ITM2A (HGNC Symbol)
Synonyms	BRICD2A, E25A
Description	Integral membrane protein 2A (HGNC Symbol)
Entrez gene summary	This gene encodes a type II membrane protein that belongs to the ITM2 family. Studies in mouse suggest that it may be involved in osteo- and chondrogenic differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Chromosome	X
Cytoband	q21.1
Chromosome location (bp)	79360384 - 79367667
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000078596 (version 83.38)
Entrez gene	9452
UniProt	O43736 (UniProt - Evidence at protein level)
neXtProt	NX_O43736
Antibodypedia	ITM2A antibodies

PROTEIN BROWSER

ITM2A-001	ITM2A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ITM2A-001 ENSP00000362395 ENST00000373298	O43736 [Direct mapping] Integral membrane protein 2A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	263 aa 29.7 kDa	No	1
ITM2A-201 ENSP00000415533 ENST00000434584	O43736 [Direct mapping] Integral membrane protein 2A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	219 aa 25 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.