Cell atlas - NRD1 - The Human Protein Atlas

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NRD1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	NRD1
Gene description	Nardilysin (N-arginine dibasic convertase)
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Mouse	Localized to the Nuclear speckles in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA053661
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA053661	HeLa	Nucleoplasm
	HPA053661	U-2 OS	Nucleoplasm
	HPA053661	U-251 MG	Nucleoplasm

MOUSE CELLS

Main location

Nuclear speckles

Mouse gene

ENSMUSG00000053510 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA053661	NIH 3T3	Nuclear speckles

GENE INFORMATION
Gene name	NRD1 (HGNC Symbol)
Synonyms	hNRD1, hNRD2
Description	Nardilysin (N-arginine dibasic convertase) (HGNC Symbol)
Entrez gene summary	This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Chromosome	1
Cytoband	p32.3
Chromosome location (bp)	51789191 - 51878937
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000078618 (version 83.38)
Entrez gene	4898
UniProt	O43847 (UniProt - Evidence at protein level)
neXtProt	NX_O43847
Antibodypedia	NRD1 antibodies

PROTEIN BROWSER

NRD1-001	NRD1-002	NRD1-003	NRD1-201	NRD1-202	NRD1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NRD1-001 ENSP00000262679 ENST00000352171	O43847 [Direct mapping] Nardilysin Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0007528 [neuromuscular junction development] GO:0008270 [zinc ion binding] GO:0008283 [cell proliferation] GO:0009986 [cell surface] GO:0016477 [cell migration] GO:0016485 [protein processing] GO:0046872 [metal ion binding] GO:0048408 [epidermal growth factor binding] GO:0051044 [positive regulation of membrane protein ectodomain proteolysis] GO:0052548 [regulation of endopeptidase activity] Show all	1151 aa 131.7 kDa	No	0
NRD1-002 ENSP00000346890 ENST00000354831	B1AKJ5 [Direct mapping] Nardilysin; Nardilysin (N-arginine dibasic convertase), isoform CRA_d Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0006508 [proteolysis] GO:0046872 [metal ion binding] Show all	1219 aa 139.4 kDa	No	0
NRD1-003 ENSP00000398464 ENST00000440943	H0Y5G9 [Direct mapping] Nardilysin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0046872 [metal ion binding] Show all	538 aa 61.7 kDa	No	0
NRD1-201 ENSP00000444416 ENST00000539524	G3V1R5 [Direct mapping] Nardilysin; Nardilysin (N-arginine dibasic convertase), isoform CRA_e Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0046872 [metal ion binding] Show all	1087 aa 125.1 kDa	No	0
NRD1-202 ENSP00000442262 ENST00000544028	F5H7V1 [Direct mapping] Nardilysin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0046872 [metal ion binding] Show all	949 aa 108.7 kDa	No	0
NRD1-203 ENSP00000481902 ENST00000615102	A0A087WYK8 [Direct mapping] Nardilysin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0046872 [metal ion binding] Show all	1148 aa 131.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.