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CBFA2T2

GENERAL INFORMATION

Gene name

 CBFA2T2

Gene description

 Core-binding factor, runt domain, alpha subunit 2; translocated to, 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

 Supported based on 1 antibody.
HPA060523
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Cervical cancer

STAINING SUMMARY
HPA060523

GENE INFORMATION

Gene name

 CBFA2T2 (HGNC Symbol)

Synonyms

 MTGR1, ZMYND3

Description

 Core-binding factor, runt domain, alpha subunit 2; translocated to, 2 (HGNC Symbol)

Entrez gene summary

 In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

Chromosome location (bp)

 33490075 - 33650036

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000078699 (version 83.38)

Entrez gene

 9139

UniProt

 O43439 (UniProt - Evidence at protein level)

neXtProt

 NX_O43439

Antibodypedia

 CBFA2T2 antibodies

PROTEIN BROWSER
CBFA2T2-003
CBFA2T2-004
CBFA2T2-005
CBFA2T2-007
CBFA2T2-009
CBFA2T2-201
CBFA2T2-202
CBFA2T2-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CBFA2T2-003
ENSP00000364428
ENST00000375279
O43439 [Direct mapping]
Protein CBFA2T2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0010976 [positive regulation of neuron projection development]
GO:0010977 [negative regulation of neuron projection development]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
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 604 aa
67.1 kDa 		No 0
CBFA2T2-004
ENSP00000433270
ENST00000492345
O43439 [Direct mapping]
Protein CBFA2T2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0010976 [positive regulation of neuron projection development]
GO:0010977 [negative regulation of neuron projection development]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
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 575 aa
63.9 kDa 		No 0
CBFA2T2-005
ENSP00000341865
ENST00000344201
O43439 [Direct mapping]
Protein CBFA2T2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0010976 [positive regulation of neuron projection development]
GO:0010977 [negative regulation of neuron projection development]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
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 263 aa
28.6 kDa 		No 0
CBFA2T2-007
ENSP00000352622
ENST00000359606
O43439 [Direct mapping]
Protein CBFA2T2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0010976 [positive regulation of neuron projection development]
GO:0010977 [negative regulation of neuron projection development]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
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 614 aa
68 kDa 		No 0
CBFA2T2-009
ENSP00000345810
ENST00000342704
O43439 [Direct mapping]
Protein CBFA2T2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0010976 [positive regulation of neuron projection development]
GO:0010977 [negative regulation of neuron projection development]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
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 595 aa
65.9 kDa 		No 0
CBFA2T2-201
ENSP00000262653
ENST00000346541
O43439 [Direct mapping]
Protein CBFA2T2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0010976 [positive regulation of neuron projection development]
GO:0010977 [negative regulation of neuron projection development]
GO:0030855 [epithelial cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
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 604 aa
67.1 kDa 		No 0
CBFA2T2-202
ENSP00000380902
ENST00000397800
O43439 [Direct mapping]
Protein CBFA2T2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0010976 [positive regulation of neuron projection development]
GO:0010977 [negative regulation of neuron projection development]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 575 aa
63.9 kDa 		No 0
CBFA2T2-203
ENSP00000443398
ENST00000543126
Q68DC6 [Direct mapping]
Protein CBFA2T2; Putative uncharacterized protein DKFZp313F2116
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
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 152 aa
16.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.