Expression of THOC1 in cancer - Summary

GENERAL INFORMATION
Gene name	THOC1
Gene description	THO complex 1
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in several tissues at variable levels, which in some tissues was combined with cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA019096 , HPA019687
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable), ovarian cancer (favourable), breast cancer (favourable) and urothelial cancer (favourable).
Renal cancer p<0.001 Liver cancer p<0.001 Ovarian cancer p<0.001 Breast cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA019096	HPA019687

GENE INFORMATION
Gene name	THOC1 (HGNC Symbol)
Synonyms	HPR1, P84
Description	THO complex 1 (HGNC Symbol)
Entrez gene summary	HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).[supplied by OMIM, Nov 2010]
Chromosome	18
Cytoband	p11.32
Chromosome location (bp)	214520 - 268050
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000079134 (version 83.38)
Entrez gene	9984
UniProt	Q96FV9 (UniProt - Evidence at protein level)
neXtProt	NX_Q96FV9
Antibodypedia	THOC1 antibodies

PROTEIN BROWSER

THOC1-001	THOC1-014	THOC1-020	THOC1-201	THOC1-202	THOC1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
THOC1-001 ENSP00000261600 ENST00000261600	Q96FV9 [Direct mapping] THO complex subunit 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000018 [regulation of DNA recombination] GO:0000346 [transcription export complex] GO:0000347 [THO complex] GO:0000445 [THO complex part of transcription export complex] GO:0003677 [DNA binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006396 [RNA processing] GO:0006397 [mRNA processing] GO:0006406 [mRNA export from nucleus] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0008380 [RNA splicing] GO:0016363 [nuclear matrix] GO:0016607 [nuclear speck] GO:0031297 [replication fork processing] GO:0032784 [regulation of DNA-templated transcription, elongation] GO:0032786 [positive regulation of DNA-templated transcription, elongation] GO:0045171 [intercellular bridge] GO:0046784 [viral mRNA export from host cell nucleus] GO:0048297 [negative regulation of isotype switching to IgA isotypes] GO:2000002 [negative regulation of DNA damage checkpoint] Show all	657 aa 75.7 kDa	No	0
THOC1-014 ENSP00000473499 ENST00000584642	R4GN58 [Direct mapping] THO complex subunit 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		95 aa 11.2 kDa	No	0
THOC1-020 ENSP00000473276 ENST00000579891	R4GMN4 [Direct mapping] THO complex subunit 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		272 aa 31.9 kDa	No	0
THOC1-201 ENSP00000480460 ENST00000616322	A0A087WWS1 [Direct mapping] THO complex subunit 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007165 [signal transduction] Show all	657 aa 75.7 kDa	No	0
THOC1-202 ENSP00000481599 ENST00000621904	A0A087WY84 [Direct mapping] THO complex subunit 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		360 aa 41.5 kDa	No	0
THOC1-203 ENSP00000486359 ENST00000631280	J3QQZ3 [Direct mapping] THO complex subunit 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		121 aa 14.1 kDa	No	1