Expression of LXN in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

LXN

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LXN
Gene description	Latexin
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HUVEC TERT2, MCF7)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA014179 , CAB025128
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014179	CAB025128

GENE INFORMATION
Gene name	LXN
Synonyms
Description	Latexin (HGNC Symbol)
Entrez gene summary	This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. [provided by RefSeq, Oct 2008]
Chromosome	3
Cytoband	q25.32
Chromosome location (bp)	158645822 - 158672693
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000079257 (version 83.38)
Entrez gene	56925
UniProt	Q9BS40 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BS40
Antibodypedia	LXN antibodies

PROTEIN BROWSER

LXN-001	LXN-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LXN-001 ENSP00000264265 ENST00000264265	Q9BS40 [Direct mapping] Latexin Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006954 [inflammatory response] GO:0008191 [metalloendopeptidase inhibitor activity] GO:0008201 [heparin binding] GO:0010951 [negative regulation of endopeptidase activity] GO:0050965 [detection of temperature stimulus involved in sensory perception of pain] GO:0070062 [extracellular exosome] Show all	222 aa 25.7 kDa	No	0
LXN-002 ENSP00000419373 ENST00000482640	H7C5A4 [Direct mapping] Latexin Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		157 aa 17.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.