Expression of TNS1 in cancer - Summary - The Human Protein Atlas

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TNS1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TNS1
Gene description	Tensin 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (ASC TERT1, REH, TIME)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression at variables levels.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 3 antibodies. HPA036089 , HPA036090 , CAB018774
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable) and urothelial cancer (unfavourable).
Colorectal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036089	HPA036090	CAB018774

GENE INFORMATION
Gene name	TNS1 (HGNC Symbol)
Synonyms	DKFZp586K0617, MXRA6, PPP1R155, TNS
Description	Tensin 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Chromosome	2
Cytoband	q35
Chromosome location (bp)	217799789 - 218002995
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000079308 (version 83.38)
Entrez gene	7145
UniProt	Q9HBL0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HBL0
Antibodypedia	TNS1 antibodies

PROTEIN BROWSER

TNS1-001	TNS1-002	TNS1-004	TNS1-005	TNS1-006	TNS1-008	TNS1-009	TNS1-013	TNS1-014	TNS1-015	TNS1-016	TNS1-020	TNS1-201	TNS1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TNS1-001 ENSP00000171887 ENST00000171887	Q9HBL0 [Direct mapping] Tensin-1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005925 [focal adhesion] GO:0007044 [cell-substrate junction assembly] GO:0009986 [cell surface] GO:0010761 [fibroblast migration] GO:0030055 [cell-substrate junction] GO:0044822 [poly(A) RNA binding] Show all	1735 aa 185.7 kDa	No	0
TNS1-002 ENSP00000405460 ENST00000446903	E7ERH1 [Direct mapping] Tensin-1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0035556 [intracellular signal transduction] GO:0046872 [metal ion binding] Show all	780 aa 85.7 kDa	No	0
TNS1-004 ENSP00000408724 ENST00000419504	E9PF55 [Direct mapping] Tensin-1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1721 aa 184.2 kDa	No	0
TNS1-005 ENSP00000406016 ENST00000430930	E9PGF5 [Direct mapping] Tensin-1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1714 aa 183.2 kDa	No	0
TNS1-006 ENSP00000400383 ENST00000413554	E7EMG1 [Direct mapping] Tensin-1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	487 aa 53.8 kDa	No	0
TNS1-008 ENSP00000308321 ENST00000310858	Q9HBL0 [Direct mapping] Tensin-1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005925 [focal adhesion] GO:0009986 [cell surface] GO:0044822 [poly(A) RNA binding] Show all	416 aa 47.2 kDa	No	0
TNS1-009 ENSP00000394171 ENST00000446688	H0Y4U1 [Direct mapping] Tensin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	846 aa 89 kDa	No	0
TNS1-013 ENSP00000395615 ENST00000413280	C9JI43 [Direct mapping] Tensin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		103 aa 11.8 kDa	No	0
TNS1-014 ENSP00000393925 ENST00000449814	C9JZT0 [Direct mapping] Tensin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		24 aa 2.8 kDa	No	0
TNS1-015 ENSP00000411349 ENST00000423413	C9J8K5 [Direct mapping] Tensin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		122 aa 13.3 kDa	No	0
TNS1-016 ENSP00000404477 ENST00000439083	C9JFT7 [Direct mapping] Tensin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		61 aa 6.9 kDa	No	0
TNS1-020 ENSP00000414704 ENST00000453356	H7C3Z4 [Direct mapping] Tensin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	149 aa 16.5 kDa	No	0
TNS1-201 ENSP00000484271 ENST00000611415	E9PF55 [Direct mapping] Tensin-1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1721 aa 184.2 kDa	No	0
TNS1-202 ENSP00000480559 ENST00000615025	A0A087WWW7 [Direct mapping] Tensin-1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1365 aa 143.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.