Expression of SAR1A in cancer - Summary - The Human Protein Atlas

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SAR1A

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SAR1A
Gene description	Secretion associated, Ras related GTPase 1A
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 3 antibodies. HPA006923 , HPA048368 , CAB022545
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable) and liver cancer (unfavourable).
Head and neck cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA006923	HPA048368	CAB022545

GENE INFORMATION
Gene name	SAR1A (HGNC Symbol)
Synonyms	SAR1, Sara, SARA1
Description	Secretion associated, Ras related GTPase 1A (HGNC Symbol)
Entrez gene summary
Chromosome	10
Cytoband	q22.1
Chromosome location (bp)	70147289 - 70170523
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000079332 (version 83.38)
Entrez gene	56681
UniProt	Q9NR31 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NR31
Antibodypedia	SAR1A antibodies

PROTEIN BROWSER

SAR1A-001	SAR1A-002	SAR1A-003	SAR1A-004	SAR1A-005	SAR1A-007	SAR1A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SAR1A-001 ENSP00000362338 ENST00000373241	Q9NR31 [Direct mapping] GTP-binding protein SAR1a Q5SQT9 [Target identity:100%; Query identity:100%] SAR1 gene homolog A (S. cerevisiae), isoform CRA_a; Small GTP-binding protein Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005794 [Golgi apparatus] GO:0006886 [intracellular protein transport] GO:0007264 [small GTPase mediated signal transduction] GO:0070062 [extracellular exosome] Show all	198 aa 22.4 kDa	No	0
SAR1A-002 ENSP00000362336 ENST00000373239	X1WI22 [Direct mapping] GTP-binding protein SAR1a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	51 aa 5.8 kDa	No	0
SAR1A-003 ENSP00000362335 ENST00000373238	Q9NR31 [Direct mapping] GTP-binding protein SAR1a Q5SQT9 [Target identity:100%; Query identity:100%] SAR1 gene homolog A (S. cerevisiae), isoform CRA_a; Small GTP-binding protein Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005794 [Golgi apparatus] GO:0006886 [intracellular protein transport] GO:0007264 [small GTPase mediated signal transduction] GO:0070062 [extracellular exosome] Show all	198 aa 22.4 kDa	No	0
SAR1A-004 ENSP00000362333 ENST00000373236	Q5SQT8 [Direct mapping] GTP-binding protein SAR1a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] Show all	121 aa 13.7 kDa	No	0
SAR1A-005 ENSP00000398165 ENST00000452767	H0Y5E8 [Direct mapping] GTP-binding protein SAR1a Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] Show all	115 aa 13 kDa	Yes	0
SAR1A-007 ENSP00000362339 ENST00000373242	Q9NR31 [Direct mapping] GTP-binding protein SAR1a Q5SQT9 [Target identity:100%; Query identity:100%] SAR1 gene homolog A (S. cerevisiae), isoform CRA_a; Small GTP-binding protein Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0006886 [intracellular protein transport] GO:0007264 [small GTPase mediated signal transduction] GO:0016192 [vesicle-mediated transport] GO:0016529 [sarcoplasmic reticulum] GO:0070062 [extracellular exosome] GO:1901301 [regulation of cargo loading into COPII-coated vesicle] GO:1901303 [negative regulation of cargo loading into COPII-coated vesicle] Show all	198 aa 22.4 kDa	No	0
SAR1A-201 ENSP00000399698 ENST00000431664	Q9NR31 [Direct mapping] GTP-binding protein SAR1a Q5SQT9 [Target identity:100%; Query identity:100%] SAR1 gene homolog A (S. cerevisiae), isoform CRA_a; Small GTP-binding protein Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005794 [Golgi apparatus] GO:0006886 [intracellular protein transport] GO:0007264 [small GTPase mediated signal transduction] GO:0070062 [extracellular exosome] Show all	198 aa 22.4 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.