Expression of CEACAM1 in cancer - Summary

GENERAL INFORMATION
Gene name	CEACAM1
Gene description	Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
Protein class	CD markers Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (CAPAN-2, Hep G2, RT4, SK-MEL-30)
HPA (normal tissue):	Tissue enhanced (colon, rectum)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in a few tissues, most abundant in glandular epithelia of the gastrointestinal tract, bile canaliculi of liver and intercalated ducts of salivary gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 2 antibodies. HPA011041 , CAB002146
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA011041	CAB002146

GENE INFORMATION
Gene name	CEACAM1 (HGNC Symbol)
Synonyms	BGP, BGP1, CD66a
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	42507304 - 42561234
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000079385 (version 83.38)
Entrez gene	634
UniProt	P13688 (UniProt - Evidence at protein level)
neXtProt	NX_P13688
Antibodypedia	CEACAM1 antibodies

PROTEIN BROWSER

CEACAM1-001	CEACAM1-002	CEACAM1-006	CEACAM1-007	CEACAM1-011	CEACAM1-012	CEACAM1-013	CEACAM1-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CEACAM1-001 ENSP00000161559 ENST00000161559	P13688 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007229 [integrin-mediated signaling pathway] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0042803 [protein homodimerization activity] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] Show all	526 aa 57.6 kDa	Yes	1
CEACAM1-002 ENSP00000384709 ENST00000403444	P13688 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007229 [integrin-mediated signaling pathway] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0042803 [protein homodimerization activity] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] Show all	464 aa 50.5 kDa	Yes	1
CEACAM1-006 ENSP00000384083 ENST00000403461	P13688 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007229 [integrin-mediated signaling pathway] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0042803 [protein homodimerization activity] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] Show all	368 aa 39.9 kDa	Yes	1
CEACAM1-007 ENSP00000472633 ENST00000471298	M0R2K4 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	94 aa 10.4 kDa	No	0
CEACAM1-011 ENSP00000244291 ENST00000352591	P13688 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007229 [integrin-mediated signaling pathway] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0042803 [protein homodimerization activity] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] Show all	430 aa 46.9 kDa	Yes	1
CEACAM1-012 ENSP00000351165 ENST00000358394	P13688 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007229 [integrin-mediated signaling pathway] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0042803 [protein homodimerization activity] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] Show all	461 aa 50.3 kDa	Yes	1
CEACAM1-013 ENSP00000471918 ENST00000599389	P13688 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007229 [integrin-mediated signaling pathway] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0042803 [protein homodimerization activity] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] Show all	399 aa 43.1 kDa	Yes	1
CEACAM1-014 ENSP00000471566 ENST00000600172	M0R109 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	99 aa 11 kDa	No	0