Expression of CIC in cancer - Summary - The Human Protein Atlas

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CIC

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CIC
Gene description	Capicua transcriptional repressor
Protein class	Cancer-related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA044341 , CAB026388
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044341	CAB026388

GENE INFORMATION
Gene name	CIC (HGNC Symbol)
Synonyms	KIAA0306
Description	Capicua transcriptional repressor (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	42268537 - 42295797
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000079432 (version 83.38)
Entrez gene	23152
UniProt	Q96RK0 (UniProt - Evidence at protein level)
neXtProt	NX_Q96RK0
Antibodypedia	CIC antibodies

PROTEIN BROWSER

CIC-001	CIC-002	CIC-005	CIC-006	CIC-007	CIC-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CIC-001 ENSP00000458663 ENST00000575354	Q96RK0 [Direct mapping] Protein capicua homolog Show all	Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0048286 [lung alveolus development] Show all	1608 aa 163.8 kDa	No	0
CIC-002 ENSP00000459719 ENST00000572681	I3L2J0 [Direct mapping] Protein capicua homolog Show all	Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005634 [nucleus] Show all	2514 aa 257.7 kDa	No	0
CIC-005 ENSP00000160740 ENST00000160740	A0A0A0MQR4 [Direct mapping] Protein capicua homolog Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005634 [nucleus] Show all	1606 aa 163.7 kDa	No	0
CIC-006 ENSP00000459011 ENST00000576505	I3L1Q4 [Direct mapping] Protein capicua homolog Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005634 [nucleus] Show all	320 aa 33.8 kDa	No	0
CIC-007 ENSP00000458543 ENST00000573349	I3L135 [Direct mapping] Protein capicua homolog Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005634 [nucleus] Show all	309 aa 32.9 kDa	No	0
CIC-008 ENSP00000459704 ENST00000571942	I3L2I4 [Direct mapping] Protein capicua homolog Show all	Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005634 [nucleus] Show all	144 aa 15 kDa	No	0

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The Human Protein Atlas

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