Expression of PAFAH1B3 in cancer - Summary

GENERAL INFORMATION
Gene name	PAFAH1B3
Gene description	Platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several tissues, including a subsets of immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA035639
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA035639

GENE INFORMATION
Gene name	PAFAH1B3
Synonyms
Description	Platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) (HGNC Symbol)
Entrez gene summary	This gene encodes an acetylhydrolase that catalyzes the removal of an acetyl group from the glycerol backbone of platelet-activating factor. The encoded enzyme is a subunit of the platelet-activating factor acetylhydrolase isoform 1B complex, which consists of the catalytic beta and gamma subunits and the regulatory alpha subunit. This complex functions in brain development. A translocation between this gene on chromosome 19 and the CDC-like kinase 2 gene on chromosome 1 has been observed, and was associated with mental retardation, ataxia, and atrophy of the brain. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	42297033 - 42303546
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000079462 (version 83.38)
Entrez gene	5050
UniProt	Q15102 (UniProt - Evidence at protein level)
neXtProt	NX_Q15102
Antibodypedia	PAFAH1B3 antibodies

PROTEIN BROWSER

PAFAH1B3-001	PAFAH1B3-002	PAFAH1B3-003	PAFAH1B3-004	PAFAH1B3-006	PAFAH1B3-007	PAFAH1B3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PAFAH1B3-001 ENSP00000262890 ENST00000262890	Q15102 [Direct mapping] Platelet-activating factor acetylhydrolase IB subunit gamma A0A024R0L6 [Target identity:100%; Query identity:100%] Platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003847 [1-alkyl-2-acetylglycerophosphocholine esterase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006629 [lipid metabolic process] GO:0007399 [nervous system development] GO:0007420 [brain development] GO:0016020 [membrane] GO:0016042 [lipid catabolic process] GO:0042802 [identical protein binding] GO:0047179 [platelet-activating factor acetyltransferase activity] GO:0070062 [extracellular exosome] Show all	231 aa 25.7 kDa	No	0
PAFAH1B3-002 ENSP00000469352 ENST00000599778	M0QXS6 [Direct mapping] Platelet-activating factor acetylhydrolase IB subunit gamma Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0007420 [brain development] GO:0047179 [platelet-activating factor acetyltransferase activity] Show all	95 aa 10.8 kDa	No	0
PAFAH1B3-003 ENSP00000472950 ENST00000601865	M0R323 [Direct mapping] Platelet-activating factor acetylhydrolase IB subunit gamma Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0007420 [brain development] GO:0047179 [platelet-activating factor acetyltransferase activity] Show all	96 aa 10.9 kDa	No	0
PAFAH1B3-004 ENSP00000473065 ENST00000595530	M0R389 [Direct mapping] Platelet-activating factor acetylhydrolase IB subunit gamma Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0007420 [brain development] GO:0047179 [platelet-activating factor acetyltransferase activity] Show all	165 aa 18.4 kDa	No	0
PAFAH1B3-006 ENSP00000470753 ENST00000596265	M0QZT2 [Direct mapping] Platelet-activating factor acetylhydrolase IB subunit gamma Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0007420 [brain development] GO:0047179 [platelet-activating factor acetyltransferase activity] Show all	140 aa 15.7 kDa	No	0
PAFAH1B3-007 ENSP00000471933 ENST00000594989	M0R1K3 [Direct mapping] Platelet-activating factor acetylhydrolase IB subunit gamma Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0007420 [brain development] GO:0047179 [platelet-activating factor acetyltransferase activity] Show all	202 aa 22.5 kDa	No	0
PAFAH1B3-201 ENSP00000444935 ENST00000538771	Q15102 [Direct mapping] Platelet-activating factor acetylhydrolase IB subunit gamma A0A024R0L6 [Target identity:100%; Query identity:100%] Platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003847 [1-alkyl-2-acetylglycerophosphocholine esterase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006629 [lipid metabolic process] GO:0007283 [spermatogenesis] GO:0007399 [nervous system development] GO:0007420 [brain development] GO:0016020 [membrane] GO:0016042 [lipid catabolic process] GO:0042802 [identical protein binding] GO:0046982 [protein heterodimerization activity] GO:0047179 [platelet-activating factor acetyltransferase activity] GO:0070062 [extracellular exosome] Show all	231 aa 25.7 kDa	No	0