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KIF22

GENERAL INFORMATION

Gene name

 KIF22

Gene description

 Kinesin family member 22

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA041076
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Renal cancer

STAINING SUMMARY
HPA041076

GENE INFORMATION

Gene name

 KIF22 (HGNC Symbol)

Synonyms

 Kid, KNSL4, OBP-1, OBP-2

Description

 Kinesin family member 22 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

 16

Cytoband

 p11.2

Chromosome location (bp)

 29790719 - 29805385

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000079616 (version 83.38)

Entrez gene

 3835

UniProt

 Q14807 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14807

Antibodypedia

 KIF22 antibodies

PROTEIN BROWSER
KIF22-001
KIF22-002
KIF22-005
KIF22-007
KIF22-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KIF22-001
ENSP00000160827
ENST00000160827
Q14807 [Direct mapping]
Kinesin-like protein KIF22
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000776 [kinetochore]
GO:0000785 [chromatin]
GO:0003677 [DNA binding]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0005925 [focal adhesion]
GO:0006281 [DNA repair]
GO:0007018 [microtubule-based movement]
GO:0007062 [sister chromatid cohesion]
GO:0007067 [mitotic nuclear division]
GO:0007080 [mitotic metaphase plate congression]
GO:0007596 [blood coagulation]
GO:0008017 [microtubule binding]
GO:0016887 [ATPase activity]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0051310 [metaphase plate congression]
GO:0072686 [mitotic spindle]
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 665 aa
73.3 kDa 		No 0
KIF22-002
ENSP00000383562
ENST00000400751
Q14807 [Direct mapping]
Kinesin-like protein KIF22
A0A024R632 [Target identity:100%; Query identity:100%]
Kinesin-like protein
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000776 [kinetochore]
GO:0003677 [DNA binding]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0005925 [focal adhesion]
GO:0006281 [DNA repair]
GO:0007018 [microtubule-based movement]
GO:0007062 [sister chromatid cohesion]
GO:0007067 [mitotic nuclear division]
GO:0007080 [mitotic metaphase plate congression]
GO:0007596 [blood coagulation]
GO:0008017 [microtubule binding]
GO:0016887 [ATPase activity]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0051310 [metaphase plate congression]
GO:0072686 [mitotic spindle]
Show all
 597 aa
66.3 kDa 		No 0
KIF22-005
ENSP00000454957
ENST00000561482
Q14807 [Direct mapping]
Kinesin-like protein KIF22
A0A024R632 [Target identity:100%; Query identity:100%]
Kinesin-like protein
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000776 [kinetochore]
GO:0003677 [DNA binding]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0005925 [focal adhesion]
GO:0006281 [DNA repair]
GO:0007018 [microtubule-based movement]
GO:0007062 [sister chromatid cohesion]
GO:0007067 [mitotic nuclear division]
GO:0007080 [mitotic metaphase plate congression]
GO:0007596 [blood coagulation]
GO:0008017 [microtubule binding]
GO:0016887 [ATPase activity]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0051310 [metaphase plate congression]
GO:0072686 [mitotic spindle]
Show all
 597 aa
66.3 kDa 		No 0
KIF22-007
ENSP00000456165
ENST00000569382
H3BRB3 [Direct mapping]
Kinesin-like protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0005925 [focal adhesion]
GO:0006281 [DNA repair]
GO:0007018 [microtubule-based movement]
GO:0008017 [microtubule binding]
GO:0016887 [ATPase activity]
Show all
 611 aa
67.8 kDa 		No 0
KIF22-012
ENSP00000457176
ENST00000569636
H3BTH5 [Direct mapping]
Kinesin-like protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
Show all
 185 aa
20.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.