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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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DNM2
  • premium

    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

DNM2

Gene description

Dynamin 2

Protein class

Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic and membranous expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
HPA054246
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (unfavourable) and head and neck cancer (favourable).
Liver cancer p<0.001
Head and neck cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA054246

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant tissues showed moderate to strong cytoplasmic positivity with additional membranous positivity in several cases. Several cases of hepatocellular carcinomas, thyroid and endometrial cancers were negative.

GENE INFORMATION

Gene name

DNM2 (HGNC Symbol)

Synonyms

CMT2M, CMTDI1, CMTDIB, DI-CMTB, DYN2, DYNII

Description

Dynamin 2 (HGNC Symbol)

Entrez gene summary

Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]

Chromosome

19

Cytoband

p13.2

Chromosome location (bp)

10718079 - 10833488

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000079805 (version 83.38)

Entrez gene

1785

UniProt

P50570 (UniProt - Evidence at protein level)

neXtProt

NX_P50570

Antibodypedia

DNM2 antibodies

PROTEIN BROWSER

DNM2-001
DNM2-002
DNM2-003
DNM2-006
DNM2-010
DNM2-012
DNM2-022
DNM2-023
DNM2-024

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DNM2-001
ENSP00000347890
ENST00000355667
P50570 [Direct mapping]
Dynamin-2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007165 [signal transduction]
GO:0008017 [microtubule binding]
GO:0014069 [postsynaptic density]
GO:0017124 [SH3 domain binding]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019899 [enzyme binding]
GO:0030426 [growth cone]
GO:0030496 [midbody]
GO:0030516 [regulation of axon extension]
GO:0030666 [endocytic vesicle membrane]
GO:0031623 [receptor internalization]
GO:0033572 [transferrin transport]
GO:0043065 [positive regulation of apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0045211 [postsynaptic membrane]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046209 [nitric oxide metabolic process]
GO:0048489 [synaptic vesicle transport]
GO:0048812 [neuron projection morphogenesis]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:1903526 [negative regulation of membrane tubulation]
Show all
870 aa
98.1 kDa
No 0
DNM2-002
ENSP00000352721
ENST00000359692
P50570 [Direct mapping]
Dynamin-2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007165 [signal transduction]
GO:0008017 [microtubule binding]
GO:0014069 [postsynaptic density]
GO:0017124 [SH3 domain binding]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019899 [enzyme binding]
GO:0030426 [growth cone]
GO:0030496 [midbody]
GO:0030516 [regulation of axon extension]
GO:0030666 [endocytic vesicle membrane]
GO:0031623 [receptor internalization]
GO:0033572 [transferrin transport]
GO:0043065 [positive regulation of apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0045211 [postsynaptic membrane]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046209 [nitric oxide metabolic process]
GO:0048489 [synaptic vesicle transport]
GO:0048812 [neuron projection morphogenesis]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:1903526 [negative regulation of membrane tubulation]
Show all
866 aa
97.7 kDa
No 0
DNM2-003
ENSP00000386192
ENST00000408974
P50570 [Direct mapping]
Dynamin-2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007165 [signal transduction]
GO:0008017 [microtubule binding]
GO:0014069 [postsynaptic density]
GO:0017124 [SH3 domain binding]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019899 [enzyme binding]
GO:0030426 [growth cone]
GO:0030496 [midbody]
GO:0030516 [regulation of axon extension]
GO:0030666 [endocytic vesicle membrane]
GO:0031623 [receptor internalization]
GO:0033572 [transferrin transport]
GO:0043065 [positive regulation of apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0045211 [postsynaptic membrane]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046209 [nitric oxide metabolic process]
GO:0048489 [synaptic vesicle transport]
GO:0048812 [neuron projection morphogenesis]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:1903526 [negative regulation of membrane tubulation]
Show all
866 aa
97.6 kDa
No 0
DNM2-006
ENSP00000468734
ENST00000585892
P50570 [Direct mapping]
Dynamin-2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007165 [signal transduction]
GO:0008017 [microtubule binding]
GO:0014069 [postsynaptic density]
GO:0017124 [SH3 domain binding]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019899 [enzyme binding]
GO:0030426 [growth cone]
GO:0030496 [midbody]
GO:0030516 [regulation of axon extension]
GO:0030666 [endocytic vesicle membrane]
GO:0031623 [receptor internalization]
GO:0033572 [transferrin transport]
GO:0043065 [positive regulation of apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0045211 [postsynaptic membrane]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046209 [nitric oxide metabolic process]
GO:0048489 [synaptic vesicle transport]
GO:0048812 [neuron projection morphogenesis]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:1903526 [negative regulation of membrane tubulation]
Show all
869 aa
98 kDa
No 0
DNM2-010
ENSP00000373905
ENST00000389253
P50570 [Direct mapping]
Dynamin-2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0001891 [phagocytic cup]
GO:0001917 [photoreceptor inner segment]
GO:0002031 [G-protein coupled receptor internalization]
GO:0003281 [ventricular septum development]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006893 [Golgi to plasma membrane transport]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008017 [microtubule binding]
GO:0009416 [response to light stimulus]
GO:0010592 [positive regulation of lamellipodium assembly]
GO:0014069 [postsynaptic density]
GO:0017124 [SH3 domain binding]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030426 [growth cone]
GO:0030496 [midbody]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030516 [regulation of axon extension]
GO:0030666 [endocytic vesicle membrane]
GO:0031623 [receptor internalization]
GO:0031749 [D2 dopamine receptor binding]
GO:0032403 [protein complex binding]
GO:0032587 [ruffle membrane]
GO:0033572 [transferrin transport]
GO:0035020 [regulation of Rac protein signal transduction]
GO:0035904 [aorta development]
GO:0036312 [phosphatidylinositol 3-kinase regulatory subunit binding]
GO:0042220 [response to cocaine]
GO:0043065 [positive regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0044281 [small molecule metabolic process]
GO:0044351 [macropinocytosis]
GO:0045211 [postsynaptic membrane]
GO:0045334 [clathrin-coated endocytic vesicle]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045807 [positive regulation of endocytosis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046209 [nitric oxide metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048489 [synaptic vesicle transport]
GO:0048812 [neuron projection morphogenesis]
GO:0050699 [WW domain binding]
GO:0050766 [positive regulation of phagocytosis]
GO:0050998 [nitric-oxide synthase binding]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0060271 [cilium morphogenesis]
GO:0060976 [coronary vasculature development]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0071245 [cellular response to carbon monoxide]
GO:0071481 [cellular response to X-ray]
GO:0071732 [cellular response to nitric oxide]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1903351 [cellular response to dopamine]
GO:1903358 [regulation of Golgi organization]
GO:1903408 [positive regulation of sodium:potassium-exchanging ATPase activity]
GO:1903526 [negative regulation of membrane tubulation]
Show all
870 aa
98 kDa
No 0
DNM2-012
ENSP00000467430
ENST00000586939
K7EPK9 [Direct mapping]
Dynamin-2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0006897 [endocytosis]
GO:0008152 [metabolic process]
Show all
51 aa
5.5 kDa
No 0
DNM2-022
ENSP00000466603
ENST00000587830
K7EMQ3 [Direct mapping]
Dynamin-2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0006897 [endocytosis]
GO:0008152 [metabolic process]
Show all
289 aa
33.7 kDa
No 0
DNM2-023
ENSP00000466914
ENST00000589106
K7ENE7 [Direct mapping]
Dynamin-2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005874 [microtubule]
GO:0006897 [endocytosis]
GO:0008152 [metabolic process]
Show all
137 aa
14.3 kDa
No 0
DNM2-024
ENSP00000466621
ENST00000591818
K7EMR9 [Direct mapping]
Dynamin-2
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
169 aa
18.2 kDa
No 0

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