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DNM2

GENERAL INFORMATION

Gene name

 DNM2

Gene description

 Dynamin 2

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic and membranous expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA054246
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and head and neck cancer (favourable).
Liver cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA054246

GENE INFORMATION

Gene name

 DNM2 (HGNC Symbol)

Synonyms

 CMT2M, CMTDI1, CMTDIB, DI-CMTB, DYN2, DYNII

Description

 Dynamin 2 (HGNC Symbol)

Entrez gene summary

 Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 10718079 - 10833488

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000079805 (version 83.38)

Entrez gene

 1785

UniProt

 P50570 (UniProt - Evidence at protein level)

neXtProt

 NX_P50570

Antibodypedia

 DNM2 antibodies

PROTEIN BROWSER
DNM2-001
DNM2-002
DNM2-003
DNM2-006
DNM2-010
DNM2-012
DNM2-022
DNM2-023
DNM2-024

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DNM2-001
ENSP00000347890
ENST00000355667
P50570 [Direct mapping]
Dynamin-2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007165 [signal transduction]
GO:0008017 [microtubule binding]
GO:0014069 [postsynaptic density]
GO:0017124 [SH3 domain binding]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019899 [enzyme binding]
GO:0030426 [growth cone]
GO:0030496 [midbody]
GO:0030516 [regulation of axon extension]
GO:0030666 [endocytic vesicle membrane]
GO:0031623 [receptor internalization]
GO:0033572 [transferrin transport]
GO:0043065 [positive regulation of apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0045211 [postsynaptic membrane]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046209 [nitric oxide metabolic process]
GO:0048489 [synaptic vesicle transport]
GO:0048812 [neuron projection morphogenesis]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:1903526 [negative regulation of membrane tubulation]
Show all
 870 aa
98.1 kDa 		No 0
DNM2-002
ENSP00000352721
ENST00000359692
P50570 [Direct mapping]
Dynamin-2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007165 [signal transduction]
GO:0008017 [microtubule binding]
GO:0014069 [postsynaptic density]
GO:0017124 [SH3 domain binding]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019899 [enzyme binding]
GO:0030426 [growth cone]
GO:0030496 [midbody]
GO:0030516 [regulation of axon extension]
GO:0030666 [endocytic vesicle membrane]
GO:0031623 [receptor internalization]
GO:0033572 [transferrin transport]
GO:0043065 [positive regulation of apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0045211 [postsynaptic membrane]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046209 [nitric oxide metabolic process]
GO:0048489 [synaptic vesicle transport]
GO:0048812 [neuron projection morphogenesis]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:1903526 [negative regulation of membrane tubulation]
Show all
 866 aa
97.7 kDa 		No 0
DNM2-003
ENSP00000386192
ENST00000408974
P50570 [Direct mapping]
Dynamin-2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007165 [signal transduction]
GO:0008017 [microtubule binding]
GO:0014069 [postsynaptic density]
GO:0017124 [SH3 domain binding]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019899 [enzyme binding]
GO:0030426 [growth cone]
GO:0030496 [midbody]
GO:0030516 [regulation of axon extension]
GO:0030666 [endocytic vesicle membrane]
GO:0031623 [receptor internalization]
GO:0033572 [transferrin transport]
GO:0043065 [positive regulation of apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0045211 [postsynaptic membrane]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046209 [nitric oxide metabolic process]
GO:0048489 [synaptic vesicle transport]
GO:0048812 [neuron projection morphogenesis]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:1903526 [negative regulation of membrane tubulation]
Show all
 866 aa
97.6 kDa 		No 0
DNM2-006
ENSP00000468734
ENST00000585892
P50570 [Direct mapping]
Dynamin-2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007165 [signal transduction]
GO:0008017 [microtubule binding]
GO:0014069 [postsynaptic density]
GO:0017124 [SH3 domain binding]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019899 [enzyme binding]
GO:0030426 [growth cone]
GO:0030496 [midbody]
GO:0030516 [regulation of axon extension]
GO:0030666 [endocytic vesicle membrane]
GO:0031623 [receptor internalization]
GO:0033572 [transferrin transport]
GO:0043065 [positive regulation of apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0045211 [postsynaptic membrane]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046209 [nitric oxide metabolic process]
GO:0048489 [synaptic vesicle transport]
GO:0048812 [neuron projection morphogenesis]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:1903526 [negative regulation of membrane tubulation]
Show all
 869 aa
98 kDa 		No 0
DNM2-010
ENSP00000373905
ENST00000389253
P50570 [Direct mapping]
Dynamin-2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0001891 [phagocytic cup]
GO:0001917 [photoreceptor inner segment]
GO:0002031 [G-protein coupled receptor internalization]
GO:0003281 [ventricular septum development]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006893 [Golgi to plasma membrane transport]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008017 [microtubule binding]
GO:0009416 [response to light stimulus]
GO:0010592 [positive regulation of lamellipodium assembly]
GO:0014069 [postsynaptic density]
GO:0017124 [SH3 domain binding]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030426 [growth cone]
GO:0030496 [midbody]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030516 [regulation of axon extension]
GO:0030666 [endocytic vesicle membrane]
GO:0031623 [receptor internalization]
GO:0031749 [D2 dopamine receptor binding]
GO:0032403 [protein complex binding]
GO:0032587 [ruffle membrane]
GO:0033572 [transferrin transport]
GO:0035020 [regulation of Rac protein signal transduction]
GO:0035904 [aorta development]
GO:0036312 [phosphatidylinositol 3-kinase regulatory subunit binding]
GO:0042220 [response to cocaine]
GO:0043065 [positive regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0044281 [small molecule metabolic process]
GO:0044351 [macropinocytosis]
GO:0045211 [postsynaptic membrane]
GO:0045334 [clathrin-coated endocytic vesicle]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045807 [positive regulation of endocytosis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046209 [nitric oxide metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048489 [synaptic vesicle transport]
GO:0048812 [neuron projection morphogenesis]
GO:0050699 [WW domain binding]
GO:0050766 [positive regulation of phagocytosis]
GO:0050998 [nitric-oxide synthase binding]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0060271 [cilium morphogenesis]
GO:0060976 [coronary vasculature development]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0071245 [cellular response to carbon monoxide]
GO:0071481 [cellular response to X-ray]
GO:0071732 [cellular response to nitric oxide]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1903351 [cellular response to dopamine]
GO:1903358 [regulation of Golgi organization]
GO:1903408 [positive regulation of sodium:potassium-exchanging ATPase activity]
GO:1903526 [negative regulation of membrane tubulation]
Show all
 870 aa
98 kDa 		No 0
DNM2-012
ENSP00000467430
ENST00000586939
K7EPK9 [Direct mapping]
Dynamin-2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0006897 [endocytosis]
GO:0008152 [metabolic process]
Show all
 51 aa
5.5 kDa 		No 0
DNM2-022
ENSP00000466603
ENST00000587830
K7EMQ3 [Direct mapping]
Dynamin-2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0006897 [endocytosis]
GO:0008152 [metabolic process]
Show all
 289 aa
33.7 kDa 		No 0
DNM2-023
ENSP00000466914
ENST00000589106
K7ENE7 [Direct mapping]
Dynamin-2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005874 [microtubule]
GO:0006897 [endocytosis]
GO:0008152 [metabolic process]
Show all
 137 aa
14.3 kDa 		No 0
DNM2-024
ENSP00000466621
ENST00000591818
K7EMR9 [Direct mapping]
Dynamin-2
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 169 aa
18.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.