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EPB41L2

GENERAL INFORMATION

Gene name

 EPB41L2

Gene description

 Erythrocyte membrane protein band 4.1-like 2

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 25
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA005730 , HPA006642
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and ovarian cancer (unfavourable).
Liver cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Endometrial cancer

STAINING SUMMARY
HPA005730
HPA006642

GENE INFORMATION

Gene name

 EPB41L2 (HGNC Symbol)

Synonyms

 4.1-G

Description

 Erythrocyte membrane protein band 4.1-like 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 6

Cytoband

Chromosome location (bp)

 130839347 - 131063322

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000079819 (version 83.38)

Entrez gene

 2037

UniProt

 O43491 (UniProt - Evidence at protein level)

neXtProt

 NX_O43491

Antibodypedia

 EPB41L2 antibodies

PROTEIN BROWSER
«
EPB41L2-001
EPB41L2-003
EPB41L2-004
EPB41L2-005
EPB41L2-006
EPB41L2-007
EPB41L2-008
EPB41L2-009
EPB41L2-010
EPB41L2-011
EPB41L2-012
EPB41L2-013
EPB41L2-014
EPB41L2-015
EPB41L2-016
EPB41L2-018
EPB41L2-021
EPB41L2-022
EPB41L2-023
EPB41L2-024
EPB41L2-025
EPB41L2-027
EPB41L2-029
EPB41L2-201
EPB41L2-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EPB41L2-001
ENSP00000338481
ENST00000337057
O43491 [Direct mapping]
Band 4.1-like protein 2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008091 [spectrin]
GO:0008092 [cytoskeletal protein binding]
GO:0008180 [COP9 signalosome]
GO:0019898 [extrinsic component of membrane]
GO:0030054 [cell junction]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0042731 [PH domain binding]
GO:0070062 [extracellular exosome]
Show all
 1005 aa
112.6 kDa 		No 0
EPB41L2-003
ENSP00000397580
ENST00000456097
H0Y5B0 [Direct mapping]
Band 4.1-like protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005856 [cytoskeleton]
GO:0008092 [cytoskeletal protein binding]
GO:0030866 [cortical actin cytoskeleton organization]
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 380 aa
42 kDa 		No 0
EPB41L2-004
ENSP00000402041
ENST00000445890
O43491 [Direct mapping]
Band 4.1-like protein 2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008091 [spectrin]
GO:0008180 [COP9 signalosome]
GO:0019898 [extrinsic component of membrane]
GO:0030054 [cell junction]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0070062 [extracellular exosome]
Show all
 747 aa
83.8 kDa 		No 0
EPB41L2-005
ENSP00000432803
ENST00000525271
O43491 [Direct mapping]
Band 4.1-like protein 2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008091 [spectrin]
GO:0008180 [COP9 signalosome]
GO:0019898 [extrinsic component of membrane]
GO:0030054 [cell junction]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0070062 [extracellular exosome]
Show all
 673 aa
76.1 kDa 		No 0
EPB41L2-006
ENSP00000376222
ENST00000392427
O43491 [Direct mapping]
Band 4.1-like protein 2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008091 [spectrin]
GO:0008180 [COP9 signalosome]
GO:0019898 [extrinsic component of membrane]
GO:0030054 [cell junction]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0070062 [extracellular exosome]
Show all
 673 aa
76.1 kDa 		No 0
EPB41L2-007
ENSP00000434576
ENST00000530481
O43491 [Direct mapping]
Band 4.1-like protein 2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008091 [spectrin]
GO:0008180 [COP9 signalosome]
GO:0019898 [extrinsic component of membrane]
GO:0030054 [cell junction]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0070062 [extracellular exosome]
Show all
 852 aa
95.5 kDa 		No 0
EPB41L2-008
ENSP00000434308
ENST00000528282
O43491 [Direct mapping]
Band 4.1-like protein 2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008091 [spectrin]
GO:0008180 [COP9 signalosome]
GO:0019898 [extrinsic component of membrane]
GO:0030054 [cell junction]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0070062 [extracellular exosome]
Show all
 747 aa
83.8 kDa 		No 0
EPB41L2-009
ENSP00000436641
ENST00000529208
E9PHY5 [Direct mapping]
Band 4.1-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0030054 [cell junction]
Show all
 935 aa
104.4 kDa 		No 0
EPB41L2-010
ENSP00000357110
ENST00000368128
O43491 [Direct mapping]
Band 4.1-like protein 2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008091 [spectrin]
GO:0008092 [cytoskeletal protein binding]
GO:0008180 [COP9 signalosome]
GO:0019898 [extrinsic component of membrane]
GO:0030054 [cell junction]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0070062 [extracellular exosome]
Show all
 1005 aa
112.6 kDa 		No 0
EPB41L2-011
ENSP00000431988
ENST00000525193
E9PII3 [Direct mapping]
Band 4.1-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0030054 [cell junction]
Show all
 706 aa
79.3 kDa 		No 0
EPB41L2-012
ENSP00000431647
ENST00000527659
E9PK52 [Direct mapping]
Band 4.1-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0030054 [cell junction]
Show all
 811 aa
91 kDa 		No 0
EPB41L2-013
ENSP00000434596
ENST00000531410
E9PPC9 [Direct mapping]
Band 4.1-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005856 [cytoskeleton]
Show all
 126 aa
13.8 kDa 		No 0
EPB41L2-014
ENSP00000437207
ENST00000524581
Q6R5J7 [Direct mapping]
4.1G isoform; Band 4.1-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005654 [nucleoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0030054 [cell junction]
GO:0030866 [cortical actin cytoskeleton organization]
Show all
 383 aa
42.2 kDa 		No 0
EPB41L2-015
ENSP00000436349
ENST00000530757
Q6ZSX4 [Direct mapping]
Band 4.1-like protein 2; cDNA FLJ45145 fis, clone BRAWH3041492, moderately similar to Homo sapiens erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) (EPB41)
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005856 [cytoskeleton]
GO:0008092 [cytoskeletal protein binding]
GO:0030866 [cortical actin cytoskeleton organization]
Show all
 201 aa
22.7 kDa 		No 0
EPB41L2-016
ENSP00000434998
ENST00000525198
E9PMG5 [Direct mapping]
Band 4.1-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
GO:0008092 [cytoskeletal protein binding]
GO:0030866 [cortical actin cytoskeleton organization]
Show all
 224 aa
24.9 kDa 		No 0
EPB41L2-018
ENSP00000436348
ENST00000527411
E9PHY5 [Direct mapping]
Band 4.1-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0030054 [cell junction]
Show all
 935 aa
104.4 kDa 		No 0
EPB41L2-021
ENSP00000435556
ENST00000530707
E9PJP4 [Direct mapping]
Band 4.1-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 118 aa
13.1 kDa 		No 0
EPB41L2-022
ENSP00000432329
ENST00000526983
E9PRG1 [Direct mapping]
Band 4.1-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 153 aa
17.1 kDa 		No 0
EPB41L2-023
ENSP00000432013
ENST00000532499
E9PIG0 [Direct mapping]
Band 4.1-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0030054 [cell junction]
Show all
 162 aa
18.1 kDa 		No 0
EPB41L2-024
ENSP00000436871
ENST00000529709
E9PQD2 [Direct mapping]
Band 4.1-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0030054 [cell junction]
Show all
 179 aa
20.2 kDa 		No 0
EPB41L2-025
ENSP00000436145
ENST00000531356
E9PQN0 [Direct mapping]
Band 4.1-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 127 aa
14.1 kDa 		No 0
EPB41L2-027
ENSP00000437295
ENST00000527423
E9PMV8 [Direct mapping]
Band 4.1-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0030054 [cell junction]
GO:0030866 [cortical actin cytoskeleton organization]
Show all
 268 aa
30.1 kDa 		No 0
EPB41L2-029
ENSP00000432949
ENST00000527017
E9PN54 [Direct mapping]
Band 4.1-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005856 [cytoskeleton]
GO:0008092 [cytoskeletal protein binding]
GO:0030866 [cortical actin cytoskeleton organization]
Show all
 240 aa
26 kDa 		No 0
EPB41L2-201
ENSP00000477544
ENST00000610431
I6L9B1 [Direct mapping]
Band 4.1-like protein 2; EPB41L2 protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0008092 [cytoskeletal protein binding]
GO:0019898 [extrinsic component of membrane]
Show all
 633 aa
71.6 kDa 		No 0
EPB41L2-202
ENSP00000486691
ENST00000628542
E9PHY5 [Direct mapping]
Band 4.1-like protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0030054 [cell junction]
Show all
 935 aa
104.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.