Cell atlas - RIF1 - The Human Protein Atlas

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RIF1

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies
	Nucleus
	Plasma membrane

Human cell
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	RIF1
Gene description	Replication timing regulatory factor 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus, plasma membrane & nuclear bodies.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported), Nuclear bodies (supported), Plasma membrane (uncertain)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA036887
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus, plasma membrane & nuclear bodies.

Main location

Nucleus (supported), Nuclear bodies (supported), Plasma membrane (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA036887	A-431	Nucleus
	HPA036887	A-431	Plasma membrane	Intensity
	HPA036887	HEK 293	Nucleus	Spatial
			Nuclear membrane	Spatial
			Nuclear bodies	Spatial
	HPA036887	U-2 OS	Nucleus
	HPA036887	U-2 OS	Plasma membrane

GENE INFORMATION
Gene name	RIF1 (HGNC Symbol)
Synonyms	FLJ10599, FLJ12870
Description	Replication timing regulatory factor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that shares homology with the yeast teleomere binding protein, Rap1 interacting factor 1. This protein localizes to aberrant telomeres may be involved in DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Chromosome	2
Cytoband	q23.3
Chromosome location (bp)	151409883 - 151508013
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000080345 (version 83.38)
Entrez gene	55183
UniProt	Q5UIP0 (UniProt - Evidence at protein level)
neXtProt	NX_Q5UIP0
Antibodypedia	RIF1 antibodies

PROTEIN BROWSER

RIF1-001	RIF1-002	RIF1-003	RIF1-004	RIF1-006	RIF1-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RIF1-001 ENSP00000243326 ENST00000243326	Q5UIP0 [Direct mapping] Telomere-associated protein RIF1 Show all	MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000723 [telomere maintenance] GO:0000781 [chromosome, telomeric region] GO:0001939 [female pronucleus] GO:0001940 [male pronucleus] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006302 [double-strand break repair] GO:0006303 [double-strand break repair via nonhomologous end joining] GO:0007049 [cell cycle] GO:0019827 [stem cell population maintenance] GO:2001034 [positive regulation of double-strand break repair via nonhomologous end joining] Show all	2472 aa 274.5 kDa	No	0
RIF1-002 ENSP00000414615 ENST00000453091	Q5UIP0 [Direct mapping] Telomere-associated protein RIF1 Show all	MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000723 [telomere maintenance] GO:0000781 [chromosome, telomeric region] GO:0005488 [binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006302 [double-strand break repair] GO:0006303 [double-strand break repair via nonhomologous end joining] GO:0007049 [cell cycle] Show all	2446 aa 271.7 kDa	No	0
RIF1-003 ENSP00000390181 ENST00000444746	Q5UIP0 [Direct mapping] Telomere-associated protein RIF1 Show all	MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000723 [telomere maintenance] GO:0000781 [chromosome, telomeric region] GO:0005488 [binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006302 [double-strand break repair] GO:0006303 [double-strand break repair via nonhomologous end joining] GO:0007049 [cell cycle] Show all	2472 aa 274.5 kDa	No	0
RIF1-004 ENSP00000415691 ENST00000428287	Q5UIP0 [Direct mapping] Telomere-associated protein RIF1 Show all	MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000723 [telomere maintenance] GO:0000781 [chromosome, telomeric region] GO:0005488 [binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006302 [double-strand break repair] GO:0006303 [double-strand break repair via nonhomologous end joining] GO:0007049 [cell cycle] Show all	2446 aa 271.7 kDa	No	0
RIF1-006 ENSP00000390486 ENST00000414861	H7BZN3 [Direct mapping] Telomere-associated protein RIF1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	845 aa 93.5 kDa	No	0
RIF1-007 ENSP00000416123 ENST00000430328	Q5UIP0 [Direct mapping] Telomere-associated protein RIF1 Show all	MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000723 [telomere maintenance] GO:0000781 [chromosome, telomeric region] GO:0005488 [binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006302 [double-strand break repair] GO:0006303 [double-strand break repair via nonhomologous end joining] GO:0007049 [cell cycle] Show all	2446 aa 271.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.