Cell atlas - SLC4A4 - The Human Protein Atlas

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SLC4A4

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	SLC4A4
Gene description	Solute carrier family 4 (sodium bicarbonate cotransporter), member 4
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (RPTEC TERT1, BJ, U-138 MG)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RPTEC TERT1, BJ, U-138 MG) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	SLC4A4 (HGNC Symbol)
Synonyms	hhNMC, HNBC1, NBC1, NBC2, pNBC, SLC4A5
Description	Solute carrier family 4 (sodium bicarbonate cotransporter), member 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Chromosome	4
Cytoband	q13.3
Chromosome location (bp)	71187286 - 71572087
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000080493 (version 83.38)
Entrez gene	8671
UniProt	Q9Y6R1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y6R1
Antibodypedia	SLC4A4 antibodies

PROTEIN BROWSER

SLC4A4-001	SLC4A4-002	SLC4A4-003	SLC4A4-004	SLC4A4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC4A4-001 ENSP00000344272 ENST00000340595	Q9Y6R1 [Direct mapping] Electrogenic sodium bicarbonate cotransporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005452 [inorganic anion exchanger activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0006820 [anion transport] GO:0008509 [anion transmembrane transporter activity] GO:0008510 [sodium:bicarbonate symporter activity] GO:0015701 [bicarbonate transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0035725 [sodium ion transmembrane transport] GO:0051453 [regulation of intracellular pH] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0098656 [anion transmembrane transport] Show all	1035 aa 116 kDa	No	>9
SLC4A4-002 ENSP00000264485 ENST00000264485	Q9Y6R1 [Direct mapping] Electrogenic sodium bicarbonate cotransporter 1 A0A024RD97 [Target identity:100%; Query identity:100%] Anion exchange protein Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005452 [inorganic anion exchanger activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0006820 [anion transport] GO:0008509 [anion transmembrane transporter activity] GO:0008510 [sodium:bicarbonate symporter activity] GO:0015701 [bicarbonate transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0035725 [sodium ion transmembrane transport] GO:0051453 [regulation of intracellular pH] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0098656 [anion transmembrane transport] Show all	1079 aa 121.5 kDa	No	>9
SLC4A4-003 ENSP00000307349 ENST00000351898	Q9Y6R1 [Direct mapping] Electrogenic sodium bicarbonate cotransporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005452 [inorganic anion exchanger activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0006820 [anion transport] GO:0008509 [anion transmembrane transporter activity] GO:0008510 [sodium:bicarbonate symporter activity] GO:0015701 [bicarbonate transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0035725 [sodium ion transmembrane transport] GO:0051453 [regulation of intracellular pH] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0098656 [anion transmembrane transport] Show all	995 aa 112.3 kDa	No	9
SLC4A4-004 ENSP00000422400 ENST00000512686	Q9Y6R1 [Direct mapping] Electrogenic sodium bicarbonate cotransporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005452 [inorganic anion exchanger activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0006820 [anion transport] GO:0008509 [anion transmembrane transporter activity] GO:0008510 [sodium:bicarbonate symporter activity] GO:0015701 [bicarbonate transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0035725 [sodium ion transmembrane transport] GO:0051453 [regulation of intracellular pH] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0098656 [anion transmembrane transport] Show all	646 aa 72 kDa	No	4
SLC4A4-201 ENSP00000393557 ENST00000425175	Q9Y6R1 [Direct mapping] Electrogenic sodium bicarbonate cotransporter 1 A5JJ20 [Target identity:100%; Query identity:100%] Anion exchange protein Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005452 [inorganic anion exchanger activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0006820 [anion transport] GO:0008509 [anion transmembrane transporter activity] GO:0008510 [sodium:bicarbonate symporter activity] GO:0015701 [bicarbonate transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0035725 [sodium ion transmembrane transport] GO:0051453 [regulation of intracellular pH] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0098656 [anion transmembrane transport] Show all	1094 aa 123.2 kDa	No	>9

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The Human Protein Atlas

The Human Protein Atlas project is funded
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