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CNOT4

GENERAL INFORMATION

Gene name

 CNOT4

Gene description

 CCR4-NOT transcription complex, subunit 4

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA005737
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CNOT4 (HGNC Symbol)

Synonyms

 CLONE243, NOT4, NOT4H

Description

 CCR4-NOT transcription complex, subunit 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]

Chromosome

 7

Cytoband

 q33

Chromosome location (bp)

 135361795 - 135510127

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000080802 (version 83.38)

Entrez gene

 4850

UniProt

 O95628 (UniProt - Evidence at protein level)

neXtProt

 NX_O95628

Antibodypedia

 CNOT4 antibodies

PROTEIN BROWSER
CNOT4-001
CNOT4-002
CNOT4-003
CNOT4-004
CNOT4-009
CNOT4-201
CNOT4-202
CNOT4-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CNOT4-001
ENSP00000406777
ENST00000423368
O95628 [Direct mapping]
CCR4-NOT transcription complex subunit 4
A0A024R781 [Target identity:100%; Query identity:100%]
CCR4-NOT transcription complex, subunit 4, isoform CRA_b
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0003676 [nucleic acid binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0016874 [ligase activity]
GO:0030014 [CCR4-NOT complex]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0051865 [protein autoubiquitination]
Show all
 642 aa
70.8 kDa 		No 0
CNOT4-002
ENSP00000399108
ENST00000428680
O95628 [Direct mapping]
CCR4-NOT transcription complex subunit 4
A0A024R776 [Target identity:100%; Query identity:100%]
CCR4-NOT transcription complex, subunit 4, isoform CRA_a
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0003676 [nucleic acid binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0016874 [ligase activity]
GO:0030014 [CCR4-NOT complex]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0051865 [protein autoubiquitination]
Show all
 572 aa
63.1 kDa 		No 0
CNOT4-003
ENSP00000388491
ENST00000451834
O95628 [Direct mapping]
CCR4-NOT transcription complex subunit 4
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0003676 [nucleic acid binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0016874 [ligase activity]
GO:0030014 [CCR4-NOT complex]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0051865 [protein autoubiquitination]
Show all
 710 aa
77.8 kDa 		No 0
CNOT4-004
ENSP00000416532
ENST00000414802
O95628 [Direct mapping]
CCR4-NOT transcription complex subunit 4
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0003676 [nucleic acid binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0016874 [ligase activity]
GO:0030014 [CCR4-NOT complex]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0051865 [protein autoubiquitination]
Show all
 433 aa
48.5 kDa 		No 0
CNOT4-009
ENSP00000354673
ENST00000361528
O95628 [Direct mapping]
CCR4-NOT transcription complex subunit 4
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0003676 [nucleic acid binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0016874 [ligase activity]
GO:0030014 [CCR4-NOT complex]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0051865 [protein autoubiquitination]
Show all
 639 aa
70.3 kDa 		No 0
CNOT4-201
ENSP00000326731
ENST00000315544
O95628 [Direct mapping]
CCR4-NOT transcription complex subunit 4
A0A024R785 [Target identity:100%; Query identity:100%]
CCR4-NOT transcription complex, subunit 4, isoform CRA_c
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0003676 [nucleic acid binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0016874 [ligase activity]
GO:0030014 [CCR4-NOT complex]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0051865 [protein autoubiquitination]
Show all
 575 aa
63.5 kDa 		No 0
CNOT4-202
ENSP00000348485
ENST00000356162
A0A0A0MRD2 [Direct mapping]
CCR4-NOT transcription complex subunit 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 175 aa
18.9 kDa 		No 0
CNOT4-203
ENSP00000445508
ENST00000541284
O95628 [Direct mapping]
CCR4-NOT transcription complex subunit 4
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0003676 [nucleic acid binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0016874 [ligase activity]
GO:0030014 [CCR4-NOT complex]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0051865 [protein autoubiquitination]
Show all
 713 aa
78.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.